Registration Dossier
Registration Dossier
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EC number: 231-198-9 | CAS number: 7446-14-2
Specific investigations: other studies
Administrative data
- Endpoint:
- behavioural effects
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- basic toxicokinetics
Test material
- Reference substance name:
- Lead sulphate
- EC Number:
- 231-198-9
- EC Name:
- Lead sulphate
- Cas Number:
- 7446-14-2
- Molecular formula:
- H2O4S.Pb
Constituent 1
Test animals
- Species:
- cattle
- Strain:
- other: Holstein calf
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 4 weeks
- Frequency of treatment:
- Twice daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1000 ppm
Basis:
nominal in diet
- No. of animals per sex per dose:
- 6
- Control animals:
- yes, plain diet
Results and discussion
- Details on results:
- Supplementation PbSO4 caused a decrease in all parameters used to study Se metabolism, e.g., absorption, tissue distribution, and endogenous excretion of Se. Absorption was decreased 26% and urinary excretion by 42%. The greater effect on excretion than on absorption indicated that Pb has an effect on Se metabolism after absorption.
Applicant's summary and conclusion
- Conclusions:
- In this study, Lead sulphate was found to interact with Selenium, inducing a low er toxicity. Yet, mechanism is unknown.
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