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EC number: 276-171-2 | CAS number: 71902-01-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
NOELR (21d) ≥ 16 mg/L for Daphnia magna (OECD 211); read-across
Key value for chemical safety assessment
Additional information
No studies are available on the toxicity of Sorbitan isooctadecanoate (CAS No. 71902-01-7) to aquatic invertebrates. The assessment was, therefore, based on studies conducted with the structurally similar category member Sorbitan stearate (CAS No. 1338-41-6). This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Both substances are UVCBs of Sorbitan fatty acid esters with partly overlapping compositions. Sorbitan isooctadecanoate consists of Sorbitan mono-, di and triesters of C18 fatty acid, with a methyl group at the penultimate carbon (iso-structure). Sorbitan stearate is also a Sorbitan ester of C16-18 fatty acids. The branching at the penultimate carbon of Sorbitan isooctadecanoate is not expected to be relevant for aquatic invertebrate toxicity, since both substances are poorly soluble in water (< 0.1 mg/L) and readily biodegradable. Additionally, short-term daphnia studies, available for both substances, demonstrated similarly low toxicity.
The key study conducted with Sorbitan stearate (CAS 1338-41-6) was performed according to OECD guideline 211 and GLP (Ministry of the Environment, Government of Japan, 2006). The test organism Daphnia magna was exposed to the test substance in a semi-static system for 21 days, at nominal concentrations of 5, 16, 50, 160 and 500 mg/L. The test concentrations 5 and 16 mg/L were prepared using tetrahydrofuran as pre-solvent. Before the test, the solvent was removed and the solution was filtered. The higher concentrations were prepared without solvent as water accommodated fractions (WAF). Since a solvent was used, the lower concentrations are not actual loading rates and these test concentrations cannot be evaluated as WAF. No inhibition of reproduction was observed during the test, in fact, the number of juveniles produced at 5 and 16 mg/L was higher than in the control. At the three higher concentrations, 100% mortality of the parental daphnia occurred, and reproduction could not be evaluated. The reported measured values for the three highest concentrations (4.65, 11.9, 17.1 mg/L) were significantly above the water solubility of the substance. Therefore, it can be assumed that undissolved test material was present and probably caused the mortality observed at the higher concentrations. Due to the methodological deficiencies in this test, the reported NOEC and EC50 need to be taken with caution. Nevertheless, at nominal concentration of 16 mg/L the test solution was reported to be clear and colourless during the test period, and no adverse effects occurred. The corresponding measured concentration 1.44 mg/L is clearly above the water solubility of Sorbitan stearate (0.01 mg/L) and was probably only attained due to the use of solvent. Therefore, 16 mg/L is used as NOELR. Sorbitan stearate is thus not expected to have adverse effects on the reproduction of daphnia magna up to the limit of water solubility.
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