Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-234-6 | CAS number: 7790-94-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Weight of evidence based on the data from the test chemicals.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- reproductive toxicity, other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from a secondary literature source.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The above experiment was performed to evaluate and assess the effect of the test chemical on the reproductive toxicity of the test animals.
- GLP compliance:
- not specified
- Justification for study design:
- No Data Available
- Specific details on test material used for the study:
- Details on test material
- Molecular weight (if other than submission substance): 36.5 g/mol
- Substance type: Inorganic
- Physical state: Liquid
- Impurities (identity and concentrations): No Data Available - Species:
- rat
- Strain:
- not specified
- Details on species / strain selection:
- No data available
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- No data Available
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure (if applicable):
- not specified
- Mass median aerodynamic diameter (MMAD):
- other: Not Specified
- Vehicle:
- not specified
- Details on exposure:
- 2 groups of 8–15 female rats were exposed to a concentration of 302 ml/m3 of the test chemical (450 mg/m3) for one hour. One group was exposed 12 days before and the other group 9 days after gestation.
- Details on mating procedure:
- No Data available
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No Data Available
- Duration of treatment / exposure:
- 12 days before gestation and 9 days after gestation.
- Frequency of treatment:
- No Data Available
- Details on study schedule:
- No Data Available
- Remarks:
- 0 and 302 ml/m3 (450 mg/m3) of the test chemical.
- No. of animals per sex per dose:
- 8-15 female rats
- Control animals:
- yes
- Details on study design:
- No data Available
- Positive control:
- No Data Available
- Parental animals: Observations and examinations:
- Clinical Signs and Mortality was observed.
- Oestrous cyclicity (parental animals):
- No Data Available
- Sperm parameters (parental animals):
- No data Available
- Litter observations:
- Clinical Signs, Mortality and body weight of the fetus was observed
- Postmortem examinations (parental animals):
- Gross Necropsy was performed.
- Postmortem examinations (offspring):
- Gross Necropsy of the offsprings was performed.
- Statistics:
- No Data Available
- Reproductive indices:
- No Data Available
- Offspring viability indices:
- No Data Available
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Dyspnoe and cyanosis was observed in all the treated animals.
- Dermal irritation (if dermal study):
- not specified
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- One-third of the animals died after the exposure to the test chemical.
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
- Reproductive function: oestrous cycle:
- not specified
- Reproductive function: sperm measures:
- not specified
- Reproductive performance:
- not specified
- Dose descriptor:
- LOAEL
- Effect level:
- 450 mg/m³ air
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- clinical signs
- mortality
- gross pathology
- Remarks on result:
- other: Not Specified
- Critical effects observed:
- not specified
- System:
- other: Not Specified
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality / viability:
- mortality observed, treatment-related
- Description (incidence and severity):
- Fetal mortality was significantly increased in the group of rats which had been exposed during gestation.
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- Among the progeny of dams which had been exposed 12 days prior to gestation, body weight gain was significantly reduced until the pups were 4 weeks old.
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Sexual maturation:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- In the male progeny of dams exposed to hydrogen chloride, functional disorders of lungs, kidneys and livers were seen in both exposure groups.
- Histopathological findings:
- not specified
- Other effects:
- not specified
- Behaviour (functional findings):
- not specified
- Developmental immunotoxicity:
- not specified
- Dose descriptor:
- LOAEL
- Generation:
- F1
- Effect level:
- 450 mg/m³ air
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- viability
- mortality
- body weight and weight gain
- gross pathology
- Remarks on result:
- other: Not Specified
- Critical effects observed:
- not specified
- System:
- other: Not Specified
- Reproductive effects observed:
- not specified
- Treatment related:
- not specified
- Conclusions:
- The LOAEL value for the test chemical after exposure of dams on 12 days before and the other group 9 days after gestation was found to be 450 mg/m3.
- Executive summary:
An inhalation study was performed to assess the effects of the test chemical on the reproductive and developmental toxicity on the test animals. In this study, 2 groups of 8–15 female rats were exposed to a concentration of 302 ml/m3 of the test chemical (450 mg/m3 ) for one hour. One group was exposed 12 days before and the other group 9 days after gestation. Both groups demonstrated symptoms of haemorrhagic oedema in the lungs, severe dyspnoe and cyanosis. One-third of the animals died. Fetal mortality was significantly increased in the group of rats which had been exposed during gestation. Among the progeny of dams which had been exposed 12 days prior to gestation, body weight gain was significantly reduced until the pups were 4 weeks old, while in the male progeny of dams exposed to hydrogen chloride, functional disorders of lungs, kidneys and livers were seen in both exposure groups.
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- reproductive toxicity, other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from a handbook or a collection of data.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD 414: PreNatal Developmental Toxicity Screening Test
- Principles of method if other than guideline:
- The above experiment was performed to assess and evaluate the effects of the test chemicals on the reproductive and developmental parameters of the test animals.
- GLP compliance:
- not specified
- Justification for study design:
- No Data Available
- Specific details on test material used for the study:
- Details on test material
- Molecular weight (if other than submission substance): 98.0778 g/mol
- Substance type: Inorganic
- Physical state: Liquid
- Impurities (identity and concentrations): No data available - Species:
- mouse
- Strain:
- CF-1
- Details on species / strain selection:
- NO Data Available
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- No Data Available
- Route of administration:
- inhalation
- Type of inhalation exposure (if applicable):
- whole body
- Vehicle:
- not specified
- Details on exposure:
- The animals were exposed to the test chemical for a period of 10 days (GD 6 to 15) for 7 hours a day.
- Details on mating procedure:
- No Data available
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No Data available
- Duration of treatment / exposure:
- 10 days.
- Frequency of treatment:
- Once (7 hours/Day)
- Details on study schedule:
- No Data available
- Remarks:
- 0, 5, 20 mg/m3 of the test chemical.
- No. of animals per sex per dose:
- No data available
- Control animals:
- yes
- Details on study design:
- No Data Available
- Positive control:
- No Data Available
- Parental animals: Observations and examinations:
- Mean Implantation, Resorptions per litter were observed.
- Oestrous cyclicity (parental animals):
- No Data Available
- Sperm parameters (parental animals):
- No Data Available
- Litter observations:
- Viability of the litters were observed.
- Postmortem examinations (parental animals):
- Implantations and Resorptions of females were counted.
- Postmortem examinations (offspring):
- No Data Available
- Statistics:
- No Data Available
- Reproductive indices:
- Implantation Index, Resorption Index
- Offspring viability indices:
- Viability Index.
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Histopathological findings: non-neoplastic:
- no effects observed
- Description (incidence and severity):
- No significant effects on mean numbers of implants/dam, and resorptions/litter were observed in mice.
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
- Reproductive function: oestrous cycle:
- not specified
- Reproductive function: sperm measures:
- not specified
- Reproductive performance:
- no effects observed
- Dose descriptor:
- NOAEL
- Effect level:
- 20 mg/m³ air
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- gross pathology
- histopathology: non-neoplastic
- reproductive performance
- Remarks on result:
- other: Not Specified
- Critical effects observed:
- not specified
- System:
- other: No Data Available
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality / viability:
- no mortality observed
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Sexual maturation:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings:
- not specified
- Other effects:
- not specified
- Behaviour (functional findings):
- not specified
- Developmental immunotoxicity:
- not specified
- Dose descriptor:
- NOEL
- Generation:
- F1
- Effect level:
- 20 mg/m³ air
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- viability
- Remarks on result:
- other: Not Specified
- Reproductive effects observed:
- not specified
- Treatment related:
- not specified
- Conclusions:
- Based on all the observations and results, it was concluded that the NOAEL for the maternal animals was 20 mg/m3 and the NOEL for fetal parameters was 20 mg/m3.
- Executive summary:
An inhalation toxicity study was conducted on the CF-1 mice, to assess and evaluate the effects on the developmental parameters of the fetuses born to the maternal animals exposed to the test chemicals. In this study, time-mated maternal animals were exposed to the test chemical in the concentration of 0, 5, 20 mg/m3 during day 6 to 15 of gestation. The animals were exposed 7hours/day to the test chemical. In maternal parameters, mean implants/dams, resorption/litter, Live fetuses were observed. Also, viability of the fetuses were observed. After all the observations, it was seen that there was no significant effects on mean numbers of implants/dam, live fetuses/litter or resorptions/litter were observed in mice. Also, there were no difference in the viability of the pups when compared to the control group. Thus, based on all the observations and results, it was concluded that the NOAEL for the maternal animals was 20 mg/m3 and the NOEL for the test chemical for fetal parameters was 20 mg/m3.
Data source
Referenceopen allclose all
- Reference Type:
- other: Assessment Report
- Title:
- Unnamed
- Year:
- 2 001
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD 414 (Pre-Natal Developmental Toxicity Screening Test)
- Principles of method if other than guideline:
- The above experiment was performed to evaluate and assess the reproductive and devlopmental toxicity of the test chemical on the test animal.
- GLP compliance:
- not specified
- Justification for study design:
- No Data Available
Test material
- Reference substance name:
- Chlorosulphuric acid
- EC Number:
- 232-234-6
- EC Name:
- Chlorosulphuric acid
- Cas Number:
- 7790-94-5
- Molecular formula:
- ClHO3S
- IUPAC Name:
- sulfurochloridic acid
- Test material form:
- not specified
- Details on test material:
- Details on test material
- Name of test material (as cited in study report): Chorosulfuric Acid
- Molecular formula (if other than submission substance): Cl-H-O3-S
- Molecular weight (if other than submission substance): 116.5239 g/mol
- Substance type: Inorganic
- Physical state: No Data Available
- Impurities (identity and concentrations): No Data Available
Constituent 1
- Specific details on test material used for the study:
- - Molecular weight (if other than submission substance): 116.5239 g/mol
- Substance type: Inorganic
- Physical state: No Data Available
- Impurities (identity and concentrations): No Data Available
Test animals
- Species:
- other: Study 2: Rat; Study 3:
- Strain:
- other: Study 2: Wistar; Study 3: CF-1
- Details on species / strain selection:
- No Data Available
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Study 2:
No Data Available
Administration / exposure
- Route of administration:
- other: Study 2: Inhalation;aerosol and 3: inhalation
- Type of inhalation exposure (if applicable):
- other: Study 3: Whole Body
- Vehicle:
- not specified
- Details on exposure:
- Study 2: 2 groups of 8–15 female rats were exposed to a concentration of 302 ml/m3 of the test chemical (450 mg/m3) for one hour. One group was exposed 12 days before and the other group 9 days after gestation.
Study 3: The animals were exposed to the test chemical for a period of 10 days (GD 6 to 15) for 7 hours a day. - Details on mating procedure:
- No Data Available
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No Data Available
- Duration of treatment / exposure:
- Study 2: 12 days before gestation and 9 days after gestation.
Study 3: 10 days. - Frequency of treatment:
- Study 2: No Data Available
Study 3: Once (7 hours/Day) - Details on study schedule:
- No Data Available
Doses / concentrations
- Remarks:
- Study 2: 0 and 302 ml/m3 (450 mg/m3) of the test chemical.
Study 3: 0, 5, 20 mg/m3 of the test chemical.
- No. of animals per sex per dose:
- Study 2: 8-15 female rats
- Control animals:
- yes
- Details on study design:
- No Data Available
- Positive control:
- No Data Available
Examinations
- Parental animals: Observations and examinations:
- Study 2: Clinical Signs and Mortality was observed.
Study 3: Mean Implantation, Resorptions per litter were observed. - Oestrous cyclicity (parental animals):
- No Data Available
- Sperm parameters (parental animals):
- No Data Available
- Litter observations:
- Study 2: Clinical Signs, Mortality and body weight of the fetus was observed
Study 3: Viability of the litters were observed. - Postmortem examinations (parental animals):
- Study 2: Gross Necropsy was performed.
Study 3: Implantations and Resorptions of females were counted. - Postmortem examinations (offspring):
- Study 2: Gross Necropsy of the offsprings was performed.
Study 3: Implantations and Resorptions of females were counted. - Statistics:
- No Data Available
- Reproductive indices:
- No Data Available
- Offspring viability indices:
- No Data Available
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Study 2: Dyspnoe and cyanosis was observed in all the treated animals.
- Dermal irritation (if dermal study):
- not specified
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- Study 2: One-third of the animals died after the exposure to the test chemical.
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Histopathological findings: non-neoplastic:
- no effects observed
- Description (incidence and severity):
- Study 3: No significant effects on mean numbers of implants/dam, and resorptions/litter were observed in mice.
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
Reproductive function / performance (P0)
- Reproductive function: oestrous cycle:
- not specified
- Reproductive function: sperm measures:
- not specified
- Reproductive performance:
- not specified
Details on results (P0)
Study 3: No significant effects on mean numbers of implants/dam, and resorptions/litter were observed in mice.
Effect levels (P0)
- Dose descriptor:
- LOAEL
- Effect level:
- 450 mg/m³ air
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- clinical signs
- mortality
- gross pathology
- Remarks on result:
- other: Not Specified
Target system / organ toxicity (P0)
- Critical effects observed:
- not specified
- System:
- other: Not Specified
Results: F1 generation
General toxicity (F1)
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality / viability:
- mortality observed, treatment-related
- Description (incidence and severity):
- Study 2: Fetal mortality was significantly increased in the group of rats which had been exposed during gestation.
Study 3: no mortality observed - Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- Study 2: Among the progeny of dams which had been exposed 12 days prior to gestation, body weight gain was significantly reduced until the pups were 4 weeks old.
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Sexual maturation:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Study 2: In the male progeny of dams exposed to hydrogen chloride, functional disorders of lungs, kidneys and livers were seen in both exposure groups.
- Histopathological findings:
- not specified
- Other effects:
- not specified
Developmental neurotoxicity (F1)
- Behaviour (functional findings):
- not specified
Developmental immunotoxicity (F1)
- Developmental immunotoxicity:
- not specified
Details on results (F1)
Study 3: No effects and viabilty of the fetus and other fetotoxicity of the test chemical.
Effect levels (F1)
- Dose descriptor:
- LOAEL
- Generation:
- F1
- Effect level:
- 450 mg/m³ air
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- viability
- mortality
- body weight and weight gain
- gross pathology
- Remarks on result:
- other: Not Specified.
Target system / organ toxicity (F1)
- Critical effects observed:
- not specified
- System:
- other: Not Specified
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
- Treatment related:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Study 2: The LOAEL value for the test chemical after exposure of dams on 12 days before and the other group 9 days after gestation was found to be 450 mg/m3.
Study 3: Based on all the observations and results, it was concluded that the NOAEL for the maternal animals was 20 mg/m3 and the NOEL for fetal parameters was 20 mg/m3. - Executive summary:
Reproductive Toxicity Studies:
The summaries of the reproductive toxicity data are as follows:
Reproductive Toxicity Study 2:
An inhalation study was performed to assess the effects of the test chemical on the reproductive and developmental toxicity on the test animals. In this study, 2 groups of 8–15 female rats were exposed to a concentration of 302 ml/m3 of the test chemical (450 mg/m3 ) for one hour. One group was exposed 12 days before and the other group 9 days after gestation. Both groups demonstrated symptoms of haemorrhagic oedema in the lungs, severe dyspnoe and cyanosis. One-third of the animals died. Fetal mortality was significantly increased in the group of rats which had been exposed during gestation. Among the progeny of dams which had been exposed 12 days prior to gestation, body weight gain was significantly reduced until the pups were 4 weeks old, while in the male progeny of dams exposed to hydrogen chloride, functional disorders of lungs, kidneys and livers were seen in both exposure groups.
Reproductive Toxicity Study 3:
An inhalation toxicity study was conducted on the CF-1 mice, to assess and evaluate the effects on the developmental parameters of the fetuses born to the maternal animals exposed to the test chemicals. In this study, time-mated maternal animals were exposed to the test chemical in the concentration of 0, 5, 20 mg/m3 during day 6 to 15 of gestation. The animals were exposed 7hours/day to the test chemical. In maternal parameters, mean implants/dams, resorption/litter, Live fetuses were observed. Also, viability of the fetuses were observed. After all the observations, it was seen that there was no significant effects on mean numbers of implants/dam, live fetuses/litter or resorptions/litter were observed in mice. Also, there were no difference in the viability of the pups when compared to the control group. Thus, based on all the observations and results, it was concluded that the NOAEL for the maternal animals was 20 mg/m3 and the NOEL for the test chemical for fetal parameters was 20 mg/m3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.