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Diss Factsheets
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EC number: 295-734-3 | CAS number: 92128-40-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- no data available: testing technically not feasible
Marine water
- Hazard assessment conclusion:
- no data available: testing technically not feasible
STP
- Hazard assessment conclusion:
- no data available: testing technically not feasible
Sediment (freshwater)
- Hazard assessment conclusion:
- no data available: testing technically not feasible
Sediment (marine water)
- Hazard assessment conclusion:
- no data available: testing technically not feasible
Hazard for air
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no data available: testing technically not feasible
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
PNECS FOR ENVIRONMENTAL COMPARTMENTS
In general, the available ecotoxicological testing data for the similar substances used in read-across indicate very low ecotoxicity for the substance.
A Water Accommodated Fraction (WAF) approach was taken to testing. The WAF approach was considered the only appropriate protocol given the extremely low water solubility of these substances. QSAR estimates of water solubility for the oxidised oils range from 10EXP(-21) – 10EXP(-12) mg/l based on Log Kow values, to 10EXP(-7) – 10EXP(-6) mg/l based on molecule fragments. In both cases it can be observed that the predicted water solubility is negligible and impossible to assess through direct physical measurements. Thus, a comparison of the available results with the expected solubility of the substance indicates that toxicity would not be expected at water saturation, resulting in a very low expected hazard for ecotoxicity. These findings generally support a Classification of no hazard for aquatic toxicity.
PNECs for environmental compartments (aquatic, sewage treatment plant [STP] microorganisms, sediments, soil and air) have not been developed at this stage due to the low ecotoxicological hazard expected, and because the available test data are not appropriate for PNEC development (i.e.,the results of WAF tests are not considered to be appropriate starting points because the concentration of substance in solution cannot be confirmed). The substances considered are expected to biodegrade in aquatic, STP, sediment and soil compartments, limiting exposure of organisms. For the case of the air compartment, the substance is considered to be virtually non-volatile, meaning that exposure in this compartment is not relevant.
PNEC FOR SECONDARY POISONING
Secondary poisoning is important to consider for substances that may accumulate through the food chain (i.e.,biomagnifying substances), posing a potential risk to higher trophic level organisms through dietary consumption. Chapter R.16 of ECHA’s Guidance for the implementation of REACH (ECHA, 2008a) provides the following “indications” for bioaccumulation potential of a substance:
1) it has a log Kow ≥ 3 and a molecular weight below 700 g/mol; or;
2) is highly adsorptive; or;
3) belongs to a class of substances known to have a potential to accumulate in living organisms; or;
4) there are indications from structural features; and
5) there is no mitigating property such as hydrolysis (half-life less than 12 hours).
The substance does not belong to any class of substances known to have a potential to accumulate in living organisms [3] nor are there any indications for bioaccumulation potential from structural features [4]. Moreover, the substance has a high molecular weight (>700 g/mol, [1]) and negligible water solubility, which means that its bioavailability and potential for adsorption through living membranes is very limited [2]. As a consequence, the risk of secondary poisoning can be discarded and no PNEC is required for secondary poisoning.
Conclusion on classification
The available toxicity values for Daphnia, Algae and Fish indicate that the substance is well above its solubility limit at the loading values. This allows inference that ecotoxicity would not be expected at the limit of water solubility for the substance.
Comparison of the available toxicity values to the T screening criterion from Chapter R.11 of ECHA Guidance (ECHA, 2008d) for acute tests of 0.1 mg/L results in screening conclusion of “presumably not T” for the substance. Due to difficulties in testing, it is generally expected that chronic fish toxicity data would not be available for similar highly hydrophobic substances, or where available, would be based on a WAF approach.
These considerations were deemed to provide sufficient evidence that toxicity will not occur in a chronic test, allowing for a weight of evidence conclusion of “not T” for the substance according to the REACH T Criteria and applicable guidance.
Although toxicity values are not available for terrestrial organisms, it is concluded that testing for terrestrial organisms can be waived because the substance will not be directly applied to soil and an indirect exposure to soil via sewage sludge transfer is unlikely since the substance is biodegradable, limiting concentrations in sewage sludge. If small amounts of the substance are present in sewage sludge transferred to soils, the substance would have low bioavailability due to a high degree of sorption to soil organic carbon, and would biodegrade further, limiting exposure by terrestrial plants, invertebrates and microorganisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.