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EC number: 801-694-5 | CAS number: 1392325-86-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The long-term toxicity and the reproductive toxicity to aquatic invertebrates (Daphnia magna) was examined in a study in accordance with OECD TG 211 and in compliance with GLP criteria. In this study, 10 replicates of one daphnid were exposed to a blank control and dilutions of 1:1573, 1:492, 1:154, 1:48, and 1:15 of a filtrate of 100 mg/L test substance for 21 days under semi-static conditions (weekly renewal). Test substance analysis was performed in fresh medium at the start of the test (day 0), and in fresh and aged media at each renewal period (days 7 and 16). Measured test concentrations ranged from 11-14% of nominal in freshly prepared test media, and 10-11 in aged test media. Time weighted average (TWA) measured concentrations were determined to be n.a. (control), 7.86, 22.4 71.1 235, and 734 µg/L.
Observations on mortality of adults and offspring occurrence were made daily. The number of offspring was counted at each water renewal and determined for each day. Dead offspring was counted if possible at each water renewal. Dead adults and offspring were removed at each water renewal day. The date of first eggs, of first brood and the number of offspring per adult in each treatment replicate was documented. Additionally, any signs of intoxication (e.g. pale adults, aborted eggs) were recorded. The validity criteria of the test were met.
At the control and the test item concentrations of 22.4, and 71.1 µg/L, one adult animal died during the test. In the test concentrations of 7.86 and 235 µg/L all parent animals survived until test end. At the highest test concentration of 734 µg/L, 6 parent animals died during the course of the test. The first offspring were recorded in the control and at the test item concentrations 22.4 and 71.1 µg/L in the daily observations on day 9, and at the lowest test concentration of 7.86 µg/L on day 8. At the concentration of 235 µg/L the first offspring was observed on day 12. At the highest test concentration of 734 µg/L, no offspring was produced. There was no significant toxic effect of the test item on the mean reproduction determined up to and including the test concentration of 7.86 µg/L. At the concentration of 22.4 µg/L, the mean reproduction per introduced and surviving daphnids was statistically significantly reduced by 25.2% live offspring compared to the control. Apart from the reported mortality and the reduced reproduction, in the highest test concentration most daphnids were recorded to be smaller and paler than in the control. Based on these findings, the EC10 of the reproduction per introduced and surviving adult was determined to be 16.3 and 14.6 µg/L, respectively. The 21 -d EC10 of 14.6 µg/L is used in the assessment.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.015 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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