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EC number: 213-367-9 | CAS number: 939-97-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
After 5-day oral administration of p-tert-butylbenzaldehyde (TBB) to rats at doses of 12.5 and 50 mg/kg bw/day, p-tert-butylbenzoic acid (TBBA) was identified as metabolite in the urine 24 hours after the last administration, but not the secondary metabolite p-tert-butylhippuric acid (TBHA) was found. Further metabolites have not been investigated. Since TBBA is only slightly water soluble, this metabolite is probably present in the urine in the form of glucuronic acid conjugate, which could not be identified by the analytic method used. Furthermore, oxidation of the p-tert-butyl group may lead to p-tert-hydroxybutylbenzoic acid and p-tert-carboxybenzoic acid as additional metabolites (Giv B-96'128).
On the occasion of various 5 day oral toxicity studies of TBB, mice, guinea pigs and dogs were administered 100 mg/kg bw/d TBB for 5 days, and urine was collected for 24 h after the last administration and analyzed for the different metabolites, i.e. TBBA and TBHA by GC analysis. TBBA was determined as metabolite in urine samples of treated dogs, guinea pigs and at very low levels in the urine of mice. However, TBHA was found to be at higher levels in urine samples of treated mice and guinea pigs compared to TBBA, whereas TBHA levels tended to be lower in the urine of dogs than TBBA levels (Giv BS-96'137).
Similar 5 day oral-toxicity menagerie studies in rats, mice, guinea pigs, dogs and monkeys have been performed with substances, which were considered to follow similar metabolic pathways, i.e. lysmeral (CAS 80 -54 -6) and t-butyltoluene (TBT, CAS 98 -51 -1). In line, considering the relation between TBBA and TBHA, the main urinary metabolite in orally treated rats, dogs and rhesus monkeys was found to be TBBA, whereas in the guinea pig and mouse TBHA predominates.
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