Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 267-023-8 | CAS number: 67762-55-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental starting date: 22 September 2020. Experimental completion date: 28 September 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- assessment report
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- Principles of method if other than guideline:
- HPLC method, designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- This study has been reviewed by the Quality Assurance Unit of Covance, and the report accurately reflects the raw data.
- Type of method:
- HPLC method
- Specific details on test material used for the study:
- Identification: ALKENES, C15-18 ALPHA-, SULFURIZED
CAS number:67762-55-4
EC number:267-023-8
Appearance/Physical state:dark red/brown liquid
Lot number:720HI434
Purity:100% UVCB
Expiry / Retest date:01 July 2022
Storage conditions:room temperature, in the dark - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 9.4
- Temp.:
- 30 °C
- pH:
- 7
- Details on results:
- A log10 Pow result of >9.4 was taken from Harlan Study Number 41203598.
- Conclusions:
- The partition coefficient of the test item has been determined to be greater than 1 x 10 E10, log10 Pow >10.0.
- Executive summary:
The determination was carried out by the HPLC Method, using a procedure designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
The test system consisted of a high performance liquid chromatograph with an appropriate detector. A reverse phase HPLC column with a very low percentage of polar groups was used and the mobile phase contained at least 25% aqueous phase.
Conclusion
The partition coefficient of the test item has been determined to be greater than 1 x 10 E10, log10 Pow >10.0.
Reference
Results
PreliminaryEstimate
A log10Powresult of >9.4 was taken from Harlan Study Number 41203598.
DefinitiveTest
Typical chromatography is presented in Appendix 1 - Attachment 2 of this Summary.
Calibration
The retention times of the dead time and the retention times, capacity factors and log10 Powvalues for the reference standards are shown in the following table:
Table 2
Standard |
Retention Time (min) |
Capacity Factor (k') |
Log10k' |
Log10Pow |
||
Injection 1 |
Injection 2 |
Mean |
||||
Thiourea (dead time) |
0.898 |
0.896 |
0.897 |
- |
- |
- |
Benzyl alcohol |
1.070 |
1.071 |
1.070 |
0.193 |
-0.714 |
1.1 |
Naphthalene |
1.752 |
1.752 |
1.752 |
0.953 |
-2.11 x 10-2 |
3.6 |
Triphenylamine |
3.959 |
3.960 |
3.960 |
3.41 |
0.533 |
5.7 |
1-Phenylnonane |
11.308 |
11.303 |
11.305 |
11.6 |
1.06 |
7.1 |
1-Phenylundecane |
21.055 |
21.053 |
21.054 |
22.5 |
1.35 |
8.1 |
1-Phenyldodecane |
29.042 |
29.037 |
29.039 |
31.4 |
1.50 |
8.7 |
1-Phenyltridecane |
40.287 |
40.281 |
40.284 |
43.9 |
1.64 |
9.4 |
1-Phenyltetradecane |
56.180 |
56.209 |
56.195 |
61.6 |
1.79 |
10.0 |
The calibration curve from which the sample results were taken from is shown as Attachment 1 of this Summary.
Partition coefficient of sample
The retention time, capacity factor and log10Powvalues determined for the sample are shown in the following table:
Table 3
Injection |
Retention Time (min) |
Capacity Factor (k') |
Log10k' |
Log10Pow |
1 |
≥71.298 |
>61.6 |
>10.0 |
>1 x 1010 |
2 |
≥71.285 |
>61.6 |
>10.0 |
>1 x 1010 |
Overall log10Pow: >10.0
Overall partition coefficient: >1 x 1010
Description of key information
The determination was carried out by the HPLC Method, using a procedure designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
The test system consisted of a high performance liquid chromatograph with an appropriate detector. A reverse phase HPLC column with a very low percentage of polar groups was used and the mobile phase contained at least 25% aqueous phase.
Conclusion
The partition coefficient of the test item has been determined to be greater than 1 x 10 E10, log10 Pow >10.0.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 10
- at the temperature of:
- 30 °C
Additional information
The determination was carried out by the HPLC Method, using a procedure designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
The test system consisted of a high performance liquid chromatograph with an appropriate detector. A reverse phase HPLC column with a very low percentage of polar groups was used and the mobile phase contained at least 25% aqueous phase.
Conclusion
The partition coefficient of the test item has been determined to be greater than 1 x 10 E10, log10 Pow >10.0.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.