Registration Dossier
Registration Dossier
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EC number: 909-152-0 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non-GLP Study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Guideline:
- other: Experimental procedure followed is outlined in the Study Report attached.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- β,1,1,2,3,3-hexamethylindan-5-ethanol
- EC Number:
- 214-934-3
- EC Name:
- β,1,1,2,3,3-hexamethylindan-5-ethanol
- Cas Number:
- 1217-08-9
- Molecular formula:
- C17H26O
- IUPAC Name:
- 2-(1,1,2,3,3-pentamethyl-2,3-dihydro-1H-inden-5-yl)propan-1-ol
- Details on test material:
- Substance CAS 1217-08-9 referred to as substance 78-003-c in the Study.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: oral intubation as a 25% w/v solution in Corn Oil
- Vehicle:
- corn oil
- Details on oral exposure:
- Vehicle noted as substance 78-003-e (Corn Oil) in the Study Report
- Doses:
- 2265 mg/kg, 2692 mg/kg, 3200 mg/kg & 3805 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- Control Acute Oral Toxicity Study in Rats separate study report. Reference Project No. 5041-78
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 300 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 928 - <= 2 672
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 900 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2 745 - <= 3 055
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 265 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 914 - <= 2 615
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- LD50 for combined males and females was calculated to be 2265 mg/kg.
- Executive summary:
LD50 for combined males and females was calculated to be 2265 mg/kg.
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