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Diss Factsheets
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EC number: 200-795-6 | CAS number: 73-22-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006-12-07 to 2007-02-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to OECD guideline 404 (adopted 2002)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Source: Harlan Italy s.r.l.
Weight: ca. 2000 g
Age: 9 – 11 weeks
Acclimatisation period: at least 10 days
Housing: individually in stainless steel cages equipped with grid floor
Diet: STANRAB (P) SQC ad libitum
Water: ad libitum
Environmental conditions:
Temperature (°C): 19 ± 2
Relative humidity (%): 55 ± 15
Photoperiod (hrs dark / hrs light): 12 / 12 by fluorescent tubes
Air changes (per hr): 15-20 - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- other: untreated skin sites of the same animal
- Amount / concentration applied:
- TEST MATERIAL
Amount applied: 0.5 g reduced to a paste with 0.1 mL sterile water - Duration of treatment / exposure:
- 4 h
- Observation period:
- up to 72 h
- Number of animals:
- 3
- Details on study design:
- TEST SITE
Area of exposure: dorsolateral part of the trunk
Type of wrap: 2.5 cm x 2.5 cm square gauze fixed by a strip of synthetic film and elastic adhesive bandage
REMOVAL OF TEST SUBSTANCE
Washing with water
Time after start of exposure: 4 h
SCORING SYSTEM
According to guideline - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 0
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal irritation of L-tryptophan was investigated with rabbits in a GLP study according to OECD guideline 404. There was no indication of a systemic effect of treatment. Changes in body weight were not remarkable. No irritation was apparent following a 4 h period of exposure to the test item. Therefore, L-tryptophan can be classified as not skin irritating.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007-02-13 to 2007-02-16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to OECD guideline 405 (adopted 2002)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Source: Harlan Italy s.r.l.
Weight: ca. 2000 g
Age: 9 – 11 weeks
Acclimatisation period: at least 10 days
Housing: individually in stainless steel cages equipped with grid floor
Diet: STANRAB (P) SQC ad libitum
Water: ad libitum
Environmental conditions:
Temperature (°C): 19 ± 2
Relative humidity (%): 55 ± 15
Photoperiod (hrs dark / hrs light): 12 / 12 by fluorescent tubes
Air changes (per hr): 15-20 - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of the same animal
- Amount / concentration applied:
- TEST MATERIAL
Amount applied: 100 mg - Duration of treatment / exposure:
- Single application
- Observation period (in vivo):
- up to 72 h
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
No rinsing
SCORING SYSTEM
According to guideline - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 0
- Irritant / corrosive response data:
- Slight redness, chemosis and discharge (scores of 1) were observed in the 3 animals at the 1 h examination. The ocular reactions were reversible in all animals within 24 h after application.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute eye irritation of L-tryptophan was investigated with rabbits in a GLP study according to OECD guideline 405. There was no indication of a systemic effect of treatment. Changes in body weight were not remarkable. A slight irritation was observed at the 1 h examination in all animals, but recovery occurred at the 24 h examination. Therefore, L-tryptophan can be classified as not eye irritating.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The acute dermal irritation of L-tryptophan was investigated with rabbits in a GLP study according to OECD guideline 404. There was no indication of a systemic effect of treatment. Changes in body weight were not remarkable. No irritation was apparent following a 4 h period of exposure to the test item. Therefore, L-tryptophan can be classified as not skin irritating.
The acute eye irritation of L-tryptophan was investigated with rabbits in a GLP study according to OECD guideline 405. There was no indication of a systemic effect of treatment. Changes in body weight were not remarkable. A slight irritation was observed at the 1 h examination in all animals, but recovery occurred at the 24 h examination. Therefore, L-tryptophan can be classified as not eye irritating.
Justification for classification or non-classification
Due to negative results in OECD guideline studies regarding irritation to skin and irritation to eyes, no classification according to EU and GHS criteria is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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