Registration Dossier
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EC number: 905-013-3 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No acute toxic effects (based on mortality) on zebra fish up to the nominal concentration of 28 mg/L (LC50 > 28 mg/L, threshold approach).
Key value for chemical safety assessment
Additional information
The test item reaction mass of isomenthone and trans-menthone (76.1% Menthone and 23.5% Isomenthone) was stable in the test medium over the test renewal periods of 24 hours. The biological results were related to the nominal concentrations of the test item. In the control and test medium with the nominal concentration of 28 mg/L all fish survived until the end of the test. No visible abnormalities were observed at the test fish in the control. At the test item concentration of 28 mg/L, sublethal effects (apathy, fish mainly at bottom of aquarium) were observed after 72 and 96 hours of exposure, but no mortality was observed.
Therefore, the 96-hour NOEC to zebra fish was determined to be < 28 mg/L due to observed sublethal effects. The 96-hour LC0 to zebra fish was determined to be at least 28 mg/L. The 96-hour LC0 might even be higher than this concentration, but concentrations higher than the lowest EC50 value obtained in tests with algae and daphnia have not been tested in this fish test, in agreement with the guidelines and with the threshold approach. The 96-hour LOEC to zebra fish was determined to be 28 mg/L due to observed sublethal effects. The LC50 and LC100 were clearly higher than 28 mg/L. These values could not be quantified due to the absence of mortality at the tested concentration.
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