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EC number: 262-062-7 | CAS number: 60113-43-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non-GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test
Test material
- Reference substance name:
- 2,6,6-trimethylbicyclo[3.1.1]heptane-3-carbaldehyde
- EC Number:
- 262-062-7
- EC Name:
- 2,6,6-trimethylbicyclo[3.1.1]heptane-3-carbaldehyde
- Cas Number:
- 60113-43-1
- Molecular formula:
- C11H18O
- IUPAC Name:
- 2,6,6-trimethylbicyclo[3.1.1]heptane-3-carbaldehyde
- Details on test material:
- Name of the test substance used in the study report: Formylpinan R
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The rats were hould in wire mesh cages. They were identified via color labelling on the tail.
Mean body weights: males 276 g, females 205 g
Age of the animals at the start of the study: 8 weeks
The rats were housed in fully air-conditioned rooms with a temperature in the range of 20 - 24°C and a relative humidity in the range of 30 - 70%. The day/night rhythm was 12 h dark and 12 h light. A standardized animal laboratory diet and drinking water were available ad libitum.
Adaption period: at least 5 days
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- other: unchanged
- Details on inhalation exposure:
- Generation of the atmosphere for inhalation: exposure
The product was filled to a height of 5 cm into a fritted glass flask (glass filter, pore-size 90 - 150 um, diameter 30 mm), and the weight was determined. The fritted glass flask containing the product was placed in a waterbath maintained at 20°C by a thermostat, and a stream of 200 l/h compressed air was introduced. The mixture of air and test substance generated in this way was passed through a glass distributor to 6 glass tubes in which 3 male and 3 female animals had been placed. The emerging mixtures of test substance and air were exhausted. Suitable measures were applied to ensure that the air supply had the same temperature as in the laboratories, so that the temperature in the exposure apparatus was between 19 and 25°C . There were no deviations from these set conditions which might have adversely affected the results of the study. After 30 minutes the fritted glass flask was replaced by a new one containing fresh test substance as described above. This generator was then used for the remainder of the test.
Determination of the nominal concentration:
The amount of test substance used was determined by reweighing the fritted glass flasks. Exposure lasted for 7 hours. The aim was to determine the exposure time survived by all animals, including an observation period of 14 days. - Duration of exposure:
- 7 h
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- Clinical examinations took place each work day. Lethality was checked each day. The animals which died, and those sacrificed with carbon dioxide at the end of the observation period, were subjected to a gross-pathological examination.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- other: saturated vapour
- Exp. duration:
- 7 h
- Remarks on result:
- other: no mortality
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 0.14 mg/L air (nominal)
- Exp. duration:
- 7 h
- Mortality:
- none
- Clinical signs:
- other: Accelerated, in some animals intermittent, respiration; slight attempts to escape; wiping of snouts, trembling in some animals.
- Gross pathology:
- Nothing abnormal found in the organs.
Any other information on results incl. tables
The mean concentration of the test substance, calculated for a test lasting 7 hours was 0.14 mg/l.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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