Registration Dossier
Registration Dossier
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EC number: 233-036-2 | CAS number: 10025-67-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Migrated data set- the study does not meet important criteria of today standard method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 944
- Report date:
- 1944
Materials and methods
- Principles of method if other than guideline:
- Method: T14-06: 25 µl of S2Cl2 was applied on the inner surface of the ear of a rabbit, afterwards:
1. no rinsing 2. rinsing after 30 or 60 sec - GLP compliance:
- no
Test material
- Reference substance name:
- Disulphur dichloride
- EC Number:
- 233-036-2
- EC Name:
- Disulphur dichloride
- Cas Number:
- 10025-67-9
- Molecular formula:
- Cl2S2
- IUPAC Name:
- dichlorodisulfane
- Details on test material:
- S2Cl2 (no data on purity)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- open
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 1. no rinsing 2. rinsing after 30 or 60 sec
- Observation period:
- 24 hours
- Number of animals:
- 1
- Details on study design:
- no further data
Results and discussion
In vivo
- Irritant / corrosive response data:
- Migrated data set
- Other effects:
- Migrated data set
Any other information on results incl. tables
Open application
1. without washing followed by fast vaporisation of substance:
after 20 min: skin is pale, transparent and without blood
after 24 hours: strong corrosion of skin, weeping, inflamation, necrosis within some days, afterwards perforation of skin which was treated with substance
2. With washing up after 1 min: slight superficial irritant effect, healing with cicatrisation within 4 weeks
after 30 seconds: slight erythema, no additional changes
Applicant's summary and conclusion
- Executive summary:
Migrated data set
method: 25 µl of S2Cl2 was applied on the inner surface of the ear of a rabbit, afterwards:
1. no rinsing 2. rinsing after 30 or 60 sec
result:
1. without washing followed by fast vaporisation of substance:
after 20 min: skin is pale, transparent and without blood
after 24 hours: strong corrosion of skin, weeping, inflamation, necrosis within some days, afterwards perforation of skin which was treated with substance
2. With washing up after 1 min: slight superficial irritant effect, healing with cicatrisation within 4 weeks
after 30 seconds: slight erythema, no additional changesreference: Gross E (1944)
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