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Diss Factsheets
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EC number: 923-835-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996-08-22 to 1996-09-23
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no autopsy at the end of the study but no death, normal clinical examination and weight evolution
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- yes
- Remarks:
- absence of autopsy at the end of the study
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - form: solid (wax)
- batch number: 908MP
- storage: room temperature
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - 5 male rats and 5 non gestating rats about 200 to 250g at the time of the trial
- source of the animals: Janvier Le Genest St Isle 53940 FRANCE
- acclimation: at least 5 days in the animal shelter of the laboratory
- house: individual polystyrene cages, room temperature between 18 and 22°C, relative humidity between 50 and 80°C, filtered and recycled air at 3000 cubic meters/hour, 12/12 hours light/dark cycle.
- food (aliment extralabo M20 Ets Pietrement) and tap water ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- paraffin oil
- Details on oral exposure:
- the single dose was administered with a syringue and the gastro-oesophageal probe.
- Doses:
- 2 g/kg
- No. of animals per sex per dose:
- 5 male rats
5 femal rats - Control animals:
- no
- Details on study design:
- - 18 hours before D0: the animals were maintained on a hydric diet
- D0: the animals were weighed. Administration of the product at 2 g/kg bw. Observation of the animals at T+ 1/4h, T+1h, up to T+6h.
- D1 to D14: daily observation of the animals. Behavioural abnormalities (apathy, excitation, palpebral ptosis), nervous attacks (comas, trembling, convulsions), digestive effects (refusal of food or drink, modification of the volume or appearance of faeces or urina) toxic and corrosif vascular effects (buccal, anal, nasal bleeding), eventual deaths
- D7: weighting of the survivals
- D14: weighting of the survivals
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- no mortality
- Clinical signs:
- absence of clinical side effects
- Body weight:
- normal weight evolution
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- The test substance has an innocuousness by oral route at a dose of 2 g/kg bw according to the protocol defined in the guideline.
- Executive summary:
The test substance was administrated in 5 male and 5 female rats at the dose of 2 g/kg bw according to the guideline EEC 884L251 25/04/84.
Mortality, clinical behavioural and weight evolution were recored for 14 days after the single oral administration.
The absence of mortality or other clinical side effects (severe apathy, loss of weight) allows to conclude in the total innocuousness of the tested product at the dose administered. This allows to classify the product as non toxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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