Registration Dossier
Registration Dossier
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EC number: 309-984-9 | CAS number: 101896-26-8 A residue from the distillation of crude benzole to remove benzole fronts. Composed primarily of benzene, toluene and xylenes boiling in the range of approximately 75°C to 200°C (167°F to 392°F).
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The absence of mutagenicity is solely based on negative findings in routine bacterial gene mutation assays. In additional testing, in particular in vivo, benzene was found to induce chromosomal aberrations and the formation of micronuclei. It is an in vivo somatic cell mutagen for mammals and man. Most relevant adverse effects in animals repeatedly exposed to benzene were observed in the haematopoietic system.
(see EU 2008, RAR benzene)
Short description of key information:
Light oil (composite sample) showed no mutagenic potential in a valid Ames test. The negative result is confirmed by the absence of mutagenicity in bacterial mutation and other in-vitro assays carried out with the key components, benzene, toluene, and mixed xylene or xylene isomers.
Endpoint Conclusion:
Justification for classification or non-classification
As benzene is a major intrinsic constituent of light oil, this mixture has to be considered and classified as mutagenic.
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