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Diss Factsheets
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EC number: 277-242-0 | CAS number: 73037-34-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Disodium oxybis[methylbenzenesulphonate]
- EC Number:
- 277-242-0
- EC Name:
- Disodium oxybis[methylbenzenesulphonate]
- Cas Number:
- 73037-34-0
- Molecular formula:
- C14H12Na2O7S2
- IUPAC Name:
- disodium oxybis(methylbenzenesulfonate)
- Test material form:
- solid
- Details on test material:
- Active content reported: 90-95 %
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: female: approx. 23-24 weeks
- Weight at study initiation: > 2 kg
- Housing: individually
- Diet ad libitum
- Water ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18
- Humidity (%): 55
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: test substance was only moistened
- Controls:
- other: The opposite site of the treatment area served as control.
- Amount / concentration applied:
- 0.5 g to each test side, moistened with water to ensure good contact to the skin.
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- up to 72 hours post treatment
- Number of animals:
- 3
- Details on study design:
- The test item ws applied first to a gauze patch.
To ensure good skin contact it was moistened with tap water.
The patch was then applied to the skin on a small area (approx 6cm² of the left side of the dorsal area ; the right side served as control).
The patch was fixed with a semi-occlusive dressing for a 4-hour period.
At the end of the exposure operiod the residual test item was removed with tap water.
All animals were observed for 72 hours after the patch removal.
Scoring for oedema and erythema was made according to Draize.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: up to 72 hours
- Score:
- ca. 0
- Max. score:
- 4
- Reversibility:
- other: no signs of erythema were reported
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: up to 72 hours
- Score:
- ca. 0
- Max. score:
- 4
- Reversibility:
- other: no signs of oedema were reported
- Irritant / corrosive response data:
- No irritant or corrosive effects were observed on the intact skin of thee female rabbits after a contact time of 4 hours.
- Other effects:
- Neither mortality nor significant clinical signs of toxicity were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
Three New Zealand white rabbits received dermal application of 0.5 g moistened ditolylether disulfonic acid disodium salt, isomer mixture to the shaved dorsal skin (left side) for 4 hours. The right side of the dosal skin served as control (OECD TG 404). The test substance was held in place by a semi-occlusive dressing. After termination of the exposure the residue test substance was removed with tap water. The animals were observed for 72 hours post treatment. Under the conditions of the study ditolylether disulfonic acid disodium salt, isomer mixture caused no irritating or corrosive skin effect. No clinical signs of systemic intoxication are observed.
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