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EC number: 221-453-2 | CAS number: 3101-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the O.E.C.D. test guideline 425 with GLP compliance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- up-and-down procedure
- Limit test:
- yes
Test material
- Reference substance name:
- p-tert-butylphenyl 1-(2,3-epoxy)propyl ether
- EC Number:
- 221-453-2
- EC Name:
- p-tert-butylphenyl 1-(2,3-epoxy)propyl ether
- Cas Number:
- 3101-60-8
- Molecular formula:
- C13H18O2
- IUPAC Name:
- 2-[(4-tert-butylphenoxy)methyl]oxirane
- Reference substance name:
- p-tert-butylphenyl-1-(2,3)-epoxypropyl ether
- IUPAC Name:
- p-tert-butylphenyl-1-(2,3)-epoxypropyl ether
- Reference substance name:
- Oxirane, 2-((4-(1,1-dimethylethyl)phenoxy)methyl)-
- IUPAC Name:
- Oxirane, 2-((4-(1,1-dimethylethyl)phenoxy)methyl)-
- Test material form:
- other: Liquid at room temperature.
- Details on test material:
- As per IUCLID5 Sections 1.1. 1.2. and 4.1.
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- The study animals were acquired from Texas Animal Specialties; Humble, TX and weighted 182-217 gm at experimental initiation. The animals were housed in suspended stainless steel with wire bottom cages, 1 per cage. The temperature was 20-22°C and relative humidity was 32-91%. There was a 12-hour light/dark cycle and 10-12 air changes/hour in the animal room. The animals were maintained on a PMI Feeds Tnc.TM Formulab #5008 diet; available ad libitum except for approximately 16 hours before dosing. Municipal water supply analyzed by TCEQ Water Utilities Division; was available ad lib itum from automatic water system.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The test substance was administered as received and was not diluted. An individual dose was calculated for each animal based on its fasted body weight and administered by gavage at a volume of 1.97 mL/kg. Each dose was administered using an appropriately sized syringe and stainless steel ball-tipped intubation needle. The animals were returned to their cages immediately after dosing.
- Doses:
- 2000 mg/Kg of body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Following oral dosing observations for mortality and clinical/behavioral signs of toxicity were made at least three times on the day of dosing (Day 0) and at least once daily thereafter for 14 days. Individual body weights were recorded just prior to dosing and on Days 7 and 14. On Day 14 after dosing, each animal was euthanized by an overdose of CO2. All study animals were subjected to gross necropsy and all abnormalities were recorded.
- Statistics:
- None required
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- approximate LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0/5 animals
- Clinical signs:
- other: Clinical signs included activity decrease and piloerection. Animals were asymptomatic by Day 4.
- Gross pathology:
- The gross necropsy conducted at termination of the study revealed no observable abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Based upon the LD50 of > 2000 mg/Kg of body weight the test substance is considered to be essentially nontoxic by the oral route of exposure.
- Executive summary:
The test substance, p-tert-butylphenyl-1 -(2,3)-epoxypropyl ether was accessed for acute oral toxicity in the rat by an O.E.C.D. test guidline 425 Up-Down procedure. Based upon the LD50 of > 2000 mg/Kg of body weight the test substance is considered to be essentially nontoxic by the oral route of exposure.
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