Registration Dossier
Registration Dossier
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EC number: 214-868-5 | CAS number: 1203-17-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Guideline:
- other: Lab SOP PH-402 followed
- Deviations:
- not specified
- Principles of method if other than guideline:
- Followed Test Facility SOP No. PH-402. Study in compliance with the Good Laboratory Practice Regulations.
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- 1,1,2,3,3-pentamethylindan
- EC Number:
- 214-868-5
- EC Name:
- 1,1,2,3,3-pentamethylindan
- Cas Number:
- 1203-17-4
- Molecular formula:
- C14H20
- IUPAC Name:
- 1,1,2,3,3-pentamethyl-2,3-dihydro-1H-indene
- Details on test material:
- Noted in study as Compound 81-205-01
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 4300, 4500, 4700 & 5000 mg/kg
- No. of animals per sex per dose:
- 10 animals per dose. 5 males and 5 females. 5 animals per sex per dose.
- Control animals:
- not specified
Results and discussion
- Preliminary study:
- Three groups of four rats per group (2 males and 2 females) were orally administered at 5000, 1600 and 500 mg/kg
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 500 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 4 286 - 4 725
Applicant's summary and conclusion
- Conclusions:
- The calculated acute oral LD50 in male and female rats is 4500 mg/kg.
- Executive summary:
The calculated acute oral LD50 in male and female rats is 4500 mg/kg.
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