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Diss Factsheets
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EC number: 230-426-4 | CAS number: 7128-64-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Inhalation toxicity was tested according to the method of Sachsse et al. (1973): Measurement of inhalation toxicity of aerosols in small laboratory animals. In: Proceedings of the Europ. Soc. for the Study of Drug Toxicity, Vol. XV, pp. 239-251, Zurich, June 1973.
- GLP compliance:
- no
- Remarks:
- prior to GLP
Test material
- Reference substance name:
- 2,5-thiophenediylbis(5-tert-butyl-1,3-benzoxazole)
- EC Number:
- 230-426-4
- EC Name:
- 2,5-thiophenediylbis(5-tert-butyl-1,3-benzoxazole)
- Cas Number:
- 7128-64-5
- Molecular formula:
- C26H26N2O2S
- IUPAC Name:
- 5-tert-butyl-2-[5-(5-tert-butyl-1,3-benzoxazol-2-yl)thiophen-2-yl]-1,3-benzoxazole
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif: RAIf (SPF) strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: in-house
- Weight at study initiation: 190 - 195 grams
- Housing: Macrolon cages, type 4 (9 animals to a cage)
- Diet: rat food - NAFAG, Gossau SG; ad libitum
- Water: ad libitum
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 1
- Humidity (%): 55 +/- 5
- Photoperiod (hrs dark / hrs light): 10/14
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: "Grafix Exaktomat Injector"
- Method of holding animals in test chamber: PVC tubes
- System of generating particulates/aerosols: nozzle under a pressure of 2 atm at a rate of 20 L/min
- Method of particle size determination: Cascade Impactor with selectron filters
- Relative humidity: 32%
TEST ATMOSPHERE
- Brief description of analytical method used: gravimetry
- Samples taken from breathing zone: yes
VEHICLE
- Composition of vehicle: air
TEST ATMOSPHERE
- Particle size distribution:
> 7 µm: ca. 56%
3-7 µm: ca. 15%
1-3 µm: ca. 11%
< 1µm: ca. 18% - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- determined gravimetrically
- Duration of exposure:
- 4 h
- Concentrations:
- 1820 mg/m³ air (maximum achievable concentration)
- No. of animals per sex per dose:
- 9 animals
- Control animals:
- no
- Details on study design:
- The animals were submitted to a necropsy at the end of the observation period.
- Statistics:
- The average dust concentration was gravimetrically determined.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1 820 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Average dust concentration, gravimetrically determined
- Mortality:
- No deaths observed
- Clinical signs:
- other: During the 4-hour exposure period and the subsequent 14-day observation period no toxic symptoms were observed.
- Gross pathology:
- No substance related gross organ changes were seen.
- Other findings:
- aerosol concentration: 1820 +/- 69 mg/m³
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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