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EC number: 800-149-9 | CAS number: 1410795-90-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The test item hydrolyses quickly at pH 1.2, 4, 7, and 9 and temperatures ranging between 20 and 60 °C. Hydrolysis products are formic acid and glycerol.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 28.6 h
- at the temperature of:
- 20 °C
Additional information
The hydrolysis of the test item 1,2,3-propanetriol, mono- and diformates was determined at the pH values 1.2, 4 and 7 according to OECD test guideline 111. At pH 9, the rate of hydrolysis was too fast for a calculation of kinetic parameters. The lowest pH of 1.2 was included to simulate hydrolysis under physiological conditions (in gastric fluid). The individual results are summarised as follows:
pH 1.2 (37 °C):kobs[h-1] = 1.350 ± 0.003;t0.5[h] = 0.513 ± 0.001
pH 4:
20 °C:kobs[h-1] = 0.002 ± 4·10-6;t0.5[h] = 374.8 ± 0.7
50 °C:kobs[h-1] = 0.018 ± 2·10-5;t0.5[h] = 0.041 ± 5·10-5
60 °C:kobs[h-1] = 37.72 ± 0.04;t0.5[h] = 16.87 ± 0.02
A[h-1] = 2.3·108
EA[kJ/mol] = 62.3 ± 0.1
pH 7:
20 °C:kobs[h-1] = 0.024 ± 2·10-5;t0.5[h] = 28.64 ± 0.03
40 °C:kobs[h-1] = 0.182 ± 1·10-4;t0.5[h] = 3.817 ± 0.003
50 °C:kobs[h-1] = 0.626 ± 0.001;t0.5[h] = 1.107 ± 0.002
60 °C:kobs[h-1] = 1.457 ± 0.003;t0.5[h] = 0.476 ± 0.001
A[h-1] = 2.2·1013
EA[kJ/mol] = 84.1 ± 0.3
The parameters for generation of the hydrolysis products could not be calculated. Different methods like HPLC and GC-MS, including derivatisation of the hydrolysis products, were investigated for their quantification, but no suitable method for measurement of degradation products could be developed.
The hydrolysis of the test item leads to generation of formic acid and glycerol. Based on the molecular structures of the test item (ester bonds) this is the only plausible mechanism for hydrolytical degradation.This result is further supported by the read-across partner ethylene diformate (source substance):
Reliable QSAR calculations (HYDROWIN v2.00) resulted in DT50 values of 1.24 d at pH 7 and 2.98 h at pH 8 (Müller, 2011). Thus, the substance will hydrolyse, yielding the expected hydrolysis products ethylene glycol and formic acid upon contact with water. Further analytical investigations in the available ecotoxicological studies performed with ethylene diformate resulted in DT50 values of 4 h in standard algae medium (OECD 201; Vryenhoef, 2013) and 11 h in standard daphnia medium (OECD 202; Vryenhoef, 2012) showing that the substance is susceptible to hydrolysis.
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