Registration Dossier
Registration Dossier
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EC number: 209-750-5 | CAS number: 592-34-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP non-guideline, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
- Reference Type:
- other: English translation (summary)
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
- Principles of method if other than guideline:
- According to BASF-internal standard: Five Gassner rats per sex per dose were exposed to the test substance dissolved in an aqueous solution with Tragacanth gum. After an exposure period of 14 days animals were necropsied.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Butyl chloroformate
- EC Number:
- 209-750-5
- EC Name:
- Butyl chloroformate
- Cas Number:
- 592-34-7
- Molecular formula:
- C5H9ClO2
- IUPAC Name:
- butyl carbonochloridate
- Details on test material:
- - Name of the test substance used in the study report: n-Butylchlorkohlensäureester; Chloroformic acid butyl ester
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Gassner rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: Males: 170 - 220g; Females 150 - 196 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Aqueous emulsion with Tragacanth
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10 and 20% (v/v) - Doses:
- - 10% test concentration: 1000, 1250 mm3/kg
- 20% test concentration: 1600, 2000, 2500 mm3/kg - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 325 mg/kg bw
- Based on:
- other: test material as 10% test substance preparation
- Remarks on result:
- other: original value: 1250 mm3/kg
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 120 mg/kg bw
- Based on:
- other: test material as 20% test substance preparation
- Remarks on result:
- other: original value: 2000 mm3/kg
- Mortality:
- - 1000 mm3/kg: 1/10 after 14 days
- 1250 mm3/kg: 5/10 after 14 days
- 1600 mm3/kg: 2/10 after 14 days
- 2000 mm3/kg: 5/10 after 14 days
- 2500 mm3/kg: 10/10 after 14 days - Clinical signs:
- other: Immediately after application all animals showed dyspnea, aqueous secretion from the oral cavity, ruffled fur, and apathy. During the observation period, hunched posture, intermittent breathing, and apathy were observed. No effects were observed after 6 d
- Gross pathology:
- Corrosion of the gastrointestinal tract, adhesive inflammatory processes in the stomach wall.
Applicant's summary and conclusion
- Interpretation of results:
- moderately toxic
- Remarks:
- Migrated information
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