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EC number: 238-735-6 | CAS number: 14691-80-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Remarks:
- Study was performed prior to the update of the REACH Regulation and prior to the validation of in vitro test methods.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Trisodium hydrogen diphosphate
- EC Number:
- 238-735-6
- EC Name:
- Trisodium hydrogen diphosphate
- Cas Number:
- 14691-80-6
- Molecular formula:
- H1O7P2Na3
- IUPAC Name:
- trisodium hydrogen (phosphonooxy)phosphonate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): trisodium pyrophosphate (synonym: trisodium hydrogen diphosphate)
- Physical state: solid
- Analytical purity: >95%
- CAS # 14691-80-6
- Lot/batch No.: RS2196
- pH: 6.9 (1% solution)
- Solubility: Soluble in water
- Stability under test conditions: Test substance was expected to be stable for the duration of the test.
- Expiration date: May 10, 2015
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Received from Robinson Services, Inc on October 3, 2012
- Age at study initiation: Young adult
- Weight at study initiation:
- Housing: The animals were signly housed in suspended stainless steel caging with mesh floors, which conform to the size recommendations in the most recent 'Guide for the care and use of laboratory animals'. Litter paper was placed beneath the cage and was changed at least 3 times a week.
- Diet (e.g. ad libitum): Harlan Teklad Global High Fiber Rabbit Diet # 2031. A designated amount of the diet was available to each rabbit (150 g/day)
- Water (e.g. ad libitum): Filtered tap water was available ad libitum.
There were no known contaminants reasonable expected to be found in the food or water at levels which would interfere with the results of this study. Analysis of food and water were conducted regularly.
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-21°C
- Humidity (%): 41-69%
- Air changes (per hr): 12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.77 g of the test mixture.
- Concentration (if solution): 65% w/w in water - Duration of treatment / exposure:
- 4 hours
- Observation period:
- Up to 72 hours
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 6cm2 intact dose site
- Type of wrap if used: semi-occlusive
The test item was placed on a 1 inch by 1 inch 4-ply gauze pad. The pad and entire trunk of each animal was then wrapped with semi-occlusive 3 inch micropore tape to avoid dislocation of the pad.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The test site was gently clensed with a 3% soap solution followed by tap water and a clean paper towel to remove any residual test substance.
- Time after start of exposure: 4 hours
SCORING SYSTEM: Draize scoring system.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: All 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects noted
- Irritation parameter:
- edema score
- Basis:
- other: all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects noted
- Other effects:
- All animals appeared active and healthy during the study. There were no signs of gross toxicity, dermal irritation and adverse pharmacologic effects or abnormal behaviour.
Any other information on results incl. tables
Table 1: Erythema/Edema
Animal No. |
Sex |
Time after patch removal |
|||
30-60 mins |
24 hrs |
48 hrs |
72 hrs |
||
3501 |
F |
0/0 |
0/0 |
0/0 |
0/0 |
3502 |
F |
0/0 |
0/0 |
0/0 |
0/0 |
3503 |
F |
0/0 |
0/0 |
0/0 |
0/0 |
Total |
0/0 |
0/0 |
0/0 |
0/0 |
|
Mean |
0/0 |
0/0 |
0/0 |
0/0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study, trisodium hydrogen diphosphate is classified as non-irritating to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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