Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-756-3 | CAS number: 17773-41-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 18 August 1998 to 28 August 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD TG 404)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-hydroxy-4-(methylthio)butyronitrile
- EC Number:
- 241-756-3
- EC Name:
- 2-hydroxy-4-(methylthio)butyronitrile
- Cas Number:
- 17773-41-0
- Molecular formula:
- C5H9NOS
- IUPAC Name:
- 2-hydroxy-4-(methylsulfanyl)butanenitrile
- Details on test material:
- - Name of test material (as cited in study report): 2-hydroxy-4-méthylthiobutyronitrile
- Physical state: pale yellow liquid
- Analytical purity: 75.77% (TOS) / 74.5 % (HPLC)
- Purity test date: no data
- Lot/batch No.: MO69
- Expiration date of the lot/batch: no data
- Storage condition of test material: at room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage Cunicole de Val de Selle, 80160 Prouzel, France.
- Age at study initiation: no data
- Weight at study initiation: the animals had a mean body weight of 2.5 +/- 0.2 kg.
- Housing: individually in polystyrene cages
- Diet : ad libitum, 112 C pelleted diet (UAR, 91360 Villemoisson-sur-Orge, France)
- Water : ad libitum, water filtered by a FG Millipore membrane (0.22 micron)
- Acclimation period: at least 5 days before the beginning of the study
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 +/- 3
- Humidity (%): 30 to 70
- Air changes (per hr): 12
- Photoperiod : 12 hrs dark / 12 hrs light
IN-LIFE DATES: From: 18 August 1998 To: 28 August 1998
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 3 minutes and 4 hours
- Observation period:
- 72 hours (when no evidence of dermal irritation)
Examination time points: 1 hour, 24, 48 and 72 hours after removal of the dressing.
14 days (when persistent cutaneous irritation) - Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: right flank (application for 4 hours), left flank (application for 3 minutes)
- Type of wrap if used: dry gauze pad
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No residual test substance was observed on removal of the dressing.
- Time after start of exposure: 3 minutes and 4 hours
SCORING SYSTEM:
Irritation evaluated for each animal according to the grading scale originally proposed by Draize and adopted by OECD test guideline 404.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.77
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritant / corrosive response data:
- After a 3-minute exposure (one animal): a well-defined erythema (grade 2) was recorded on day 1. No other cutaneous reactions were observed.
After a 4-hour exposure (three animals): a very slight or well-defined erythema (grade 1 or 2) was recorded on day 1 in all animals; it persisted up to day 3 (in one animal) or 8 (in another animal). No other cutaneous reactions were observed. - Other effects:
- None
Any other information on results incl. tables
Table: Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test
Score at time point/ Reversibility | Erythema Max. score: 4 |
Edema Max. score: 4 |
60 min | 2/2/1 | 0/0/0 |
24 h | 0/2/2 | 0/0/0 |
48 h | 0/1/1 | 0/0/0 |
72 h | 0/0/1 | 0/0/0 |
Mean scores over 24, 48 and 72 hours for each animal | 0/1/1.33 | 0/0/0 |
Average 24h, 48h, 72h calculated over all the animal tested | 1 | 0 |
Reversibility*) | c. | - |
*) Reversibility: c.=completely reversible; n.c.= not completely reversible; n= not reversible
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: CLP and EU
- Conclusions:
- Under the experimental conditions, the test substance 2-hydroxy-4-methylthiobutyronitrile is slightly irritant when applied topically to rabbits.
- Executive summary:
In an acute dermal irritation study (CIT, 1998), the potential of the test substance 2 -hydroxy-4-methylthiobutyronitrile to induce skin irritation was evaluated in three male New Zealand White rabbits according to OECD 404 guideline. The test substance (0,5 ml) was applied (undiluted) for 4 hours to an area of approximately 6 cm2 of the right flank. Test sites were covered with a semi-occlusive dressing. Animals then were observed for 3 to 14 days. Irritation was scored by the method of Draize adopted by OECD test guideline 404. In one animal, after a 3-minute exposure, a well-defined erythema was recorded on day 1. No other cutaneous reactions were observed. After a 4-hour exposure (3 animals), a very slight or well-defined erythema was recorded on day 1 in all animals. It persisted up to day 3 (in one animal) or 8 (in another animal). No other cutaneous reactions were observed.The mean value of the scores at each of the reading times (24, 48 and 72 hours) for erythema and edema calculated over all the animals tested was 0.77 and 0, respectively. Under the experimental conditions, the test substance 2-hydroxy-4-methylthiobutyronitrile is slightly irritant when applied topically to rabbits. In conclusion, according to the classification criteria laid down in Directive 67/548/EEC and CLP regulation, te test substance 2 -hydroxy-4 -methylthiobutyronitrile should not be classified as irritating to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.