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Diss Factsheets
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EC number: 256-418-0 | CAS number: 49663-84-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: read-across from a slightly water soluble chromate
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Morphogenesis of alveolar bronchiolization.
- Author:
- Nettesheim, P. and A. K. Szakal
- Year:
- 1 972
- Bibliographic source:
- Lab Invest.26(2): 210-9.
Materials and methods
- Principles of method if other than guideline:
- Chronic inhalation toxicity test: mice were exposed to test substance dust 5 and a half hour per day, 5 days per week, for 18 months.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Calcium chromate
- EC Number:
- 237-366-8
- EC Name:
- Calcium chromate
- Cas Number:
- 13765-19-0
- IUPAC Name:
- calcium dioxido(dioxo)chromium
- Details on test material:
- calcium chromate (CaCrO4) dust, ozonized gasoline fume
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Duration of treatment / exposure:
- 18 months
- Frequency of treatment:
- 5 and a half hours a day, 5 days a week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
13 mg/m3 of calcium chromate
Basis:
nominal conc.
Examinations
- Other examinations:
- bacteriologic, virologic, and parasitologic testing
Results and discussion
Results of examinations
- Clinical signs:
- not examined
- Mortality:
- not examined
- Body weight and weight changes:
- not examined
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- no effects observed
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
a concentration of 13 mg/m3of calcium chromate tested: non-carcinogenic morphological changes seen, no NOAEL identified
Applicant's summary and conclusion
- Conclusions:
- Non-cancerous morphological changes in the lower respiratory tract.
- Executive summary:
Nettesheim et al. (1972) exposed mice (C57BL/6) to filtered air, ozonized gasoline fumes or calcium chromate dust (mean geometric diameter 0.2 μm) for five and a half hours/day, five days/week. The dust was dispensed into the inlet air at a concentration of 13 mg/m3. Eighteen months after the start of the exposure, 15 mice were removed from each chamber and used for bacteriologic, virologic, and parasitologic testing and for histopathology. Results showed necrosis and hyperplasia of the bronchial and alveolar epithelia, inflammation of the underlying bronchial and bronchiolar connective tissues, and hyperplasia or atrophy of surrounding lymph nodes.
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