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Diss Factsheets
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EC number: 939-714-0 | CAS number: 1474044-77-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study follows acceptable practices. Conducted prior to GLP regulations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US FHSLA, CFR, Title 21, para. 191.12
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- di C8-C10, branched, C9 rich, alkylnaphthalene sulfonic acid
- IUPAC Name:
- di C8-C10, branched, C9 rich, alkylnaphthalene sulfonic acid
- Test material form:
- other: viscous as 50% solution in light paraffinic petroleum oil as placed on the market
- Details on test material:
- A brown-black viscous liquid:
50% DNNSA (DI C8-C10, BRANCHED, C9 RICH, ALKYLNAPHTHALENE SULFONIC ACID)
50% light paraffinic petroleum oil
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- One tenth of a milliliter of test material was instilled in one eye of each rabbit. The other eye of each rabbit remained untreated and served
as a control. The treated eyes were not washed. The rabbits were immobil ized in head stocks for 24 hours and then returned to their cages.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 ml 50% solution in light paraffinic petroleum oil as placed on the market
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- Ocular lesions were evaluated at 24, 48 and 72 hours and at 4, 7 and 14 days after treatment.
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Methods of dosing are similar to Daize procedure except untreated eye used as a control.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of 6 rabbits
- Time point:
- other: 24 h
- Score:
- 2.33
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of 6 rabbits
- Time point:
- other: 48 h
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of 6 rabbits
- Time point:
- other: 72 h
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of 6 rabbits
- Time point:
- other: 24 h
- Score:
- 1.33
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of 6 rabbits
- Time point:
- other: 48 h
- Score:
- 1.67
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of 6 rabbits
- Time point:
- other: 72 h
- Score:
- 1.83
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of 6 rabbits
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of 6 rabbits
- Time point:
- other: 48 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of 6 rabbits
- Time point:
- other: 72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of 6 rabbits
- Time point:
- other: 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of 6 rabbits
- Time point:
- other: 48 h
- Score:
- 3.83
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of 6 rabbits
- Time point:
- other: 72 h
- Score:
- 3.67
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritant / corrosive response data:
The test material is a severe primary eye irritant.- Other effects:
- No clinical signs of adverse effects were observed.
Any other information on results incl. tables
See detailed results and scoring procedure in attached document (next section).
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- DNNSA as a 50% formulation in light petroleum oil is a severe primary eye irritant in rabbits.
- Executive summary:
Synex 1052, a 50% DNNSA formulation in light petroleum oil was tested for primary eye irritation in New Zealand White rabbits.
One tenth of a milliliter of test material was instilled in one eye of each rabbit. Six rabbits were treated. The other eye of each rabbit remained untreated and served as a control. The treated eyes were not washed. The rabbits were immobilized in head stocks for 24 hours and then returned to their cages. Ocular lesions were evaluated at 24, 48 and 72 hours and at 4, 7 and 14 days after treatment.
No clinical signs of adverse systemic effects were observed. The test material is a severe primary eye irritant.
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