Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 287-625-4 | CAS number: 85566-16-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 26.5 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 10
- Dose descriptor starting point:
- NOAEL
- Value:
- 150 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 264.5 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The conversion of the oral NOAEL of 150 mg/kg bw/day to a corrected inhalatory human NOAEC was based on the different respiratory volume of the rat (0.38 m3/kg) and the different rate during light activity at work (10 m3) and standard conditions (6.7 m3). Per default, a higher absorption via inhalation was assumed as a worst case. Corrected NOAEL = 150 mg/kg * 1/0.38 m3/kg/day * 6.7 m3 (8h) / 10 m3 (8h) = 264.5 mg/m3. Since alcohols are well absorbed after oral exposure, no additional factor for increased absorption after inhalation is deemed necessary.
- AF for dose response relationship:
- 1
- Justification:
- In accordance with ECHA Guidance on information requirements and chemical safety assessment – Chapter 8: Characterisation of dose [concentration]-response for human health, for the dose-response relationship, consideration should be given to the uncertainties in the dose descriptor (NOAEL, benchmark dose…) as the surrogate for the true no-adverse-effect-level (NAEL). In this case the starting point for the DNEL calculation is a NOAEC, derived from a study which is of good quality and without uncertainties. Therefore the default assessment factor, as a standard procedure, is 1.
- AF for differences in duration of exposure:
- 2
- Justification:
- Default factor for subchronic to chronic extrapolation
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- already included in route to route extrapolation
- AF for other interspecies differences:
- 1
- Justification:
- No specific target organ toxicity (aside from peroxisome proliferation, which is not relevant for humans) was observed. The NOAEL is based on general toxicity, mainly reduced body weight. There is no indication of a mechanism that shows humans would be more sensitive than predicted by allometric scaling factors alone.
- AF for intraspecies differences:
- 5
- Justification:
- Default factor
- AF for the quality of the whole database:
- 1
- Justification:
- GLP guideline study
- AF for remaining uncertainties:
- 1
- Justification:
- Generally, toxicity of long chain alcohols decreases with increasing chain length and branching. As a conservative approach, the NOAEL of a branched C10 alcohol was used to derive the DNEL for C13-15, branched and linear alcohols. Since this already leads to the use of a lower NOAEL value, no additional safety factor is deemed necessary despite the use of read across data.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 7.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 40
- Dose descriptor starting point:
- NOAEL
- Value:
- 150 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Dermal absorption is limited due to the high lipophilicity of the chemical. A maximum of 50% was assumed.
- AF for dose response relationship:
- 1
- Justification:
- NOAEL used
- AF for differences in duration of exposure:
- 2
- Justification:
- default factor for subchronic to chronic extrapolation
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- In accordance with ECHA Guidance on information requirements and chemical safety assessment – Chapter 8: Characterisation of dose [concentration]-response for human health, allometric scaling extrapolates doses according to an overall assumption that equitoxic doses (when expressed in mg/kg bw/day) scale with body weight to the power of 0.75. This results a default allometric scaling factor for the rat when compared with humans, namely 4.
- AF for other interspecies differences:
- 1
- Justification:
- No specific target organ toxicity (aside from peroxisome proliferation, which is not relevant for humans) was observed. The NOAEL is based on general toxicity, mainly reduced body weight. There is no indication of a mechanism that shows humans would be more sensitive than predicted by allometric scaling factors alone.
- AF for intraspecies differences:
- 5
- Justification:
- Default factor
- AF for the quality of the whole database:
- 1
- Justification:
- GLP guideline study.
- AF for remaining uncertainties:
- 1
- Justification:
- Generally, toxicity of long chain alcohols decreases with increasing chain length and branching. As a conservative approach, the NOAEL of a branched C10 alcohol was used to derive the DNEL for C13-15, branched and linear alcohols. Since this already leads to the use of a lower NOAEL value, no additional safety factor is deemed necessary despite the use of read across data.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 7.5 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 20
- Dose descriptor starting point:
- NOAEL
- Value:
- 150 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 130.4 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The conversion of the rat oral NOAEL to a corrected inhalatory human NOAEC was based on the different respiratory volume of the rat (1.15 m3/kg/day). Per default, a higher absorption via inhalation was assumed as a worst case.
Corrected NOAEL = 150 mg/kg * 1/1.15 m3/kg/day = 130.4 mg/m3. Since alcohols are well absorbed after oral exposure, no additional factor for increased absorption after inhalation is deemed necessary.
- AF for dose response relationship:
- 1
- Justification:
- In accordance with ECHA Guidance on information requirements and chemical safety assessment – Chapter 8: Characterisation of dose [concentration]-response for human health, for the dose-response relationship, consideration should be given to the uncertainties in the dose descriptor (NOAEL, benchmark dose…) as the surrogate for the true no-adverse-effect-level (NAEL). In this case the starting point for the DNEL calculation is a NOAEC, derived from a study which is of good quality and without uncertainties. Therefore the default assessment factor, as a standard procedure, is 1.
- AF for differences in duration of exposure:
- 2
- Justification:
- Default factor for subchronic to chronic extrapolation
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- already included in route to route extrapolation
- AF for other interspecies differences:
- 1
- Justification:
- No specific target organ toxicity (aside from peroxisome proliferation, which is not relevant for humans) was observed. The NOAEL is based on general toxicity, mainly reduced body weight. There is no indication of a mechanism that shows humans would be more sensitive than predicted by allometric scaling factors alone.
- AF for intraspecies differences:
- 10
- Justification:
- Default factor
- AF for the quality of the whole database:
- 1
- Justification:
- GLP guideline study
- AF for remaining uncertainties:
- 1
- Justification:
- Generally, toxicity of long chain alcohols decreases with increasing chain length and branching. As a conservative approach, the NOAEL of a branched C10 alcohol was used to derive the DNEL for C13-15, branched and linear alcohols. Since this already leads to the use of a lower NOAEL value, no additional safety factor is deemed necessary despite the use of read across data.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.8 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 80
- Dose descriptor starting point:
- NOAEL
- Value:
- 150 mg/m³
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Dermal absorption is limited due to the high lipophilicity of the chemical. A maximum of 50% was assumed.
- AF for dose response relationship:
- 1
- Justification:
- NOAEL used
- AF for differences in duration of exposure:
- 2
- Justification:
- default factor for subchronic to chronic extrapolation
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- In accordance with ECHA Guidance on information requirements and chemical safety assessment – Chapter 8: Characterisation of dose [concentration]-response for human health, allometric scaling extrapolates doses according to an overall assumption that equitoxic doses (when expressed in mg/kg bw/day) scale with body weight to the power of 0.75. This results a default allometric scaling factor for the rat when compared with humans, namely 4.
- AF for other interspecies differences:
- 1
- Justification:
- No specific target organ toxicity (aside from peroxisome proliferation, which is not relevant for humans) was observed. The NOAEL is based on general toxicity, mainly reduced body weight. There is no indication of a mechanism that shows humans would be more sensitive than predicted by allometric scaling factors alone.
- AF for intraspecies differences:
- 10
- Justification:
- Default factor
- AF for the quality of the whole database:
- 1
- Justification:
- GLP guideline study.
- AF for remaining uncertainties:
- 1
- Justification:
- Generally, toxicity of long chain alcohols decreases with increasing chain length and branching. As a conservative approach, the NOAEL of a branched C10 alcohol was used to derive the DNEL for C13-15, branched and linear alcohols. Since this already leads to the use of a lower NOAEL value, no additional safety factor is deemed necessary despite the use of read across data.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.9 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 80
- Dose descriptor starting point:
- NOAEL
- Value:
- 150 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- NOAEL used
- AF for differences in duration of exposure:
- 2
- Justification:
- default factor for subchronic to chronic extrapolation
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- In accordance with ECHA Guidance on information requirements and chemical safety assessment – Chapter 8: Characterisation of dose [concentration]-response for human health, allometric scaling extrapolates doses according to an overall assumption that equitoxic doses (when expressed in mg/kg bw/day) scale with body weight to the power of 0.75. This results a default allometric scaling factor for the rat when compared with humans, namely 4.
- AF for other interspecies differences:
- 1
- Justification:
- No specific target organ toxicity (aside from peroxisome proliferation, which is not relevant for humans) was observed. The NOAEL is based on general toxicity, mainly reduced body weight. There is no indication of a mechanism that shows humans would be more sensitive than predicted by allometric scaling factors alone.
- AF for intraspecies differences:
- 10
- Justification:
- Default factor
- AF for the quality of the whole database:
- 1
- Justification:
- GLP guideline study
- AF for remaining uncertainties:
- 1
- Justification:
- Generally, toxicity of long chain alcohols decreases with increasing chain length and branching. As a conservative approach, the NOAEL of a branched C10 alcohol was used to derive the DNEL for C13-15, branched and linear alcohols. Since this already leads to the use of a lower NOAEL value, no additional safety factor is deemed necessary despite the use of read across data.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.