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Diss Factsheets
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EC number: 211-470-3 | CAS number: 646-24-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
There are no data on the toxicokinetics of NMDA. The following summary has therefore been prepared based on validated predictions of the physicochemical and toxicological properties of the substance itself and its known isomers. Evidence of the behaviour of the substance in vivo from the available toxicological studies in mammals has also been taken into consideration.
NMDA is a solid of low volatility. It is water miscible and forms strongly caustic solutions with pH of >12 at above 2 g/L concentration. Due to a purely industrial use of this substance exposure may occur via the inhalation or dermal routes. Oral exposure of man via the environment must not be considered due to the biodegradability of the substance.
Absorption
The low vapour pressure and the low dustiness of the substance favour dermal absorption. However, the very high water solubility (1E+06 mg/L) and low predicted log Kow(1.82) suggest that it is too hydrophilic to cross the lipid rich stratum corneum. Since this substance is corrosive to the skin, damage to the skin might increase penetration. Acute dermal toxicity studies are not available and therefore a worst case dermal absorption of 100% has been assumed for the risk assessment.
The partition coefficient value for the substance indicates that it is likely to be absorbed directly across the respiratory tract epithelium by passive diffusion. Inhalation absorption was taken as 100%.
Due to the water solubility the substance is likely to be readily absorbed after oral exposure. An absorption factor of 100% is taken as worst case.
Distribution
The hydrophilic nature of the substance will limit its diffusion across membranes (including the blood-brain and blood-testes barriers) and its accumulation in fatty tissue.
Metabolism
There are no studies of metabolic pathways of NMDA. Genetic toxicity tests in vitro of the similar substance MODA (CAS 148528-05-6) showed no significant (2-fold or greater) differences in effects with and without metabolic activation.
The following metabolites are expected to appear from investigations of similar diamines (e.g. published data on hexamethylene diamine (CAS 124-09-4): Oxidation of one amine group leads to 9-aminononanoic acid which is likely to be one metabolite. Also acetylated amines are common and are expected in NMDA metabolism.
Excretion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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