Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 816-285-7 | CAS number: 1263133-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7370 (Dissociation constants in water)
- Deviations:
- no
- GLP compliance:
- yes
- Dissociating properties:
- no
- No.:
- #1
- Temp.:
- 20 °C
- Remarks on result:
- other: The test substance does not dissociate under the test conditions and therefore has no dissociation constant.
- Conclusions:
- The test substance does not dissociate under the test conditions and therefore has no dissociation constant.
- Executive summary:
This study was conducted to determine the dissociation constant of the test substance according to OECD Guideline No. 112 and OPPTS 830.7370 guidelines.
The test solution concentration used [50 μg/mL for titration method and 9.6 μg/mL for spectrophotometric method] was well below the water solubility (230 mg/L) of the test material.
Experiments for determination of dissociation constant of the test substance were carried out by titrating a 50 μg/mL solution of test substance in double distilled water with a 0.0024 M standardized sodium hydroxide solution and 0.0024 M standardized hydrochloric acid solution, separately. The dissociation was examined by measuring the change in pH of the test solution after incremental additions of the standardized sodium hydroxide solution and separately by standardized hydrochloric acid solution.
As per the resulting graphs of titration of the test substance solution with 0.0024 M sodium hydroxide solution and 0.0024 M hydrochloric acid solutions, there were no prominent equivalence points and hence, it was considered that the test item does not dissociate under the test conditions.
The results obtained by the titration method were further confirmed with the spectrophotometric method by recording the UV-VIS absorption spectra of test item solutions under six different pH conditions (pH 1.0, 2.2, 5.8, 7.5, 9.1 and 10.8) and checking for any significant difference in the resulting spectra. No significant differences in the spectra of the test substance in buffers of different pH were noticed and hence, it was concluded that the test substance does not dissociate under the test conditions.
Based on the results of titration and spectrophotometric methods, it was concluded that the test substance does not dissociate under the test conditions and therefore has no dissociation constant.
Reference
Description of key information
OECD Guideline 112
Key value for chemical safety assessment
Additional information
The test substance does not dissociate under the test conditions and therefore has no dissociation constant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.