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EC number: 271-678-5 | CAS number: 68603-87-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- A read-across approach is taken from adipic acid, which is a structural analogue and serves as a good representation for the carboxylic acid mixture.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Remarks:
- HPLC
- Details on sampling:
- On Day 0, 7, 14 and 18.
- Test organisms (species):
- Daphnia magna
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Test temperature:
- 20 +- 1°C
- Nominal and measured concentrations:
- nominal: 50.0, 25.0, 12.5, 6.25 and 3.13 mg/L (common ratio: 2.0) and control group
- Details on test conditions:
- - Number of organisms: 20 animals / concentration (5 animals per test vessel)
- Exposure period: 21 d
- Exposure method: Flow-through type (Continuous supply of test solution)
- Test concentration: 50.0, 25.0, 12.5, 6.25 and 3.13 mg/L (common ratio: 2.0) and control group
- Number of vessels: 4 vessels per concentration
- Test volume: Approx. 1.8 L / vessel
- Test water temperature: 20 +-1°C
- Lighting: Room light, 16 hours light (less than 1200 lux) / 8 hours dark - Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 6.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 17.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Details on results:
- The results relate to nominal concentrations, based on test substance concentrations.
- Conclusions:
- A 21d-NOEC of 6.25 mg/L was determined for the test substance towards daphnids under exposure conditions.
- Executive summary:
A study was performed to assess the long-term toxicity of adipic acid to Daphnia magna STRAUS under flow-throug conditions in accordance with the OECD Guideline for Testing of Chemicals No. 211 'Daphnia magna, Reproduction Test'.
Daphnia magna were exposed to a range of concentrations (nominal: 50.0, 25.0, 12.5, 6.25 and 3.13 mg/L) and a control for 21 d. 20 daphnis (4 vessels, 5 animals/vessel) were exposed per concentration. The test temperature was 20 +- 1°C.
After 21 d a NOEC of 6.25 mg/L was determined for adipic acid towards daphnids under exposure conditions.
Reference
Any information on pH during the test was not reported. Regarding the effect concentrations, pH effects can be excluded, due to the low range of concentrations.
Description of key information
For the mixture no data on long-term toxicity to aquatic invertebrates are availabe. Adipic acid is applied for read-across approach. The long-term toxicity of adipic acid to aquatic invertebrates was determined in a test condicted according to OECD Guideline 211 (Daphnia magna Reproduction Test). A 21d-NOEC of 6.3 mg/L was obtained (MITI, 2002).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- 6.3 mg/L
Additional information
For the mixture no data on long-term toxicity to aquatic invertebrates are available. Adipic acid is applied for read-across approach. Adipic acid is one of the constituents of the dicarboxylic acid mixture. All constituents are homologues linear alkyl dicarboxylic acids with a chain length of four to six carbon atom. The mixture is composed of three discrete carboxylic acids. Due to the structural relationship, adipic acid is a good representative for the dicarboxylic acid mixture. Adipic acid is well assessed on behalf of the ICCA/OECD HPV-program.
The long-term toxicity of adipic acid to aquatic invertebrates was determined in a test condicted according to OECD Guideline 211 (Daphnia magna Reproduction Test). A 21d-NOEC of 6.3 mg/L was obtained. (MITI, 2002).
Any information on pH during the test was not reported. Following the discussion about concentration-dependant decrease of pH, it can be concluded that effects found in this study are likely not due pH effects, based on the low range of concentrations used in this test.
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