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Diss Factsheets
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EC number: 203-311-1 | CAS number: 105-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Concerning skin sensitisation, for diethyl carbonate (DEC) no data were identified in the available literature. Therefore, data for dimethyl carbonate (DMC) are taken into further consideration (read across). The two compounds differ with regard to the length of their ester side chain. DEC contains two ethyl and DMC contains two methyl groups. Structural similarity can be calculated by using different models/algorithms and will then result in a percentage of similarity. Using the mathematical model “Yule” from the OECD toolbox (v 2.3) a structural similarity of 88.89% is calculated (15 out of 28 possible atom pairs match to DEC, 4 out of 6 topological torsions and 4 out of 8 atom centred fragments). Although the calculated value has only an indicative character, it confirms the high structural similarity of both compounds.
Dimethyl carbonate was tested in a reduced LLNA (the protocol for the rLLNA is identical to that of the traditional LLNA with one exception, as only the highest dose level that does not induce systemic toxicity and/or excessive skin irritation is tested for skin sensitizing activity), where concentrations of 0.5, 5 and 50% have been tested. The calculated stimulation indices were given with 0.64, 0.69 and 1.71, i.e. the substance gave no indications for a skin sensitizing potential.
Dimethyl carbonate, tested at 4% in petrolatum, produced no skin sensitising reactions in a maximization test with 25 human volunteers.
Therefore it can be concluded, that also diethyl carbonate will not possess a significant skin sensitising potential.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Although for diethyl carbonate no experimental studies are available, the read across with data from dimethyl carbonate (high structural similarity of both compounds) is not indicating a significant skin sensitising potential for diethyl carbonate. Therefore, no classification according to EU and GHS criteria is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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