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EC number: 203-311-1 | CAS number: 105-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06.02.2013 to 06.03.2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Auf dem Aberg 1, 57392 Schmallenberg (Germany)
Test material
- Reference substance name:
- Diethyl carbonate
- EC Number:
- 203-311-1
- EC Name:
- Diethyl carbonate
- Cas Number:
- 105-58-8
- Molecular formula:
- C5H10O3
- IUPAC Name:
- diethyl carbonate
- Details on test material:
- - Name of test material (as cited in study report): diethyl carbonate
- Substance type: ester
- Physical state: colourless liquid
- Analytical purity: 99.94%
- Impurities (identity and concentrations): ethanol/methanol, water
- Composition of test material, percentage of components: ethanol/methanol: 0.03%, water: 0.01%
- Purity test date: 14.01.2013
- Lot/batch No.: F2012070405
- Expiration date of the lot/batch: 31.07.2014
- Storage condition of test material: test material stored dry at room temperature, well ventilated, container closed
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Fresh samples of activated sludge were collected from the sewage treatment plant Ruhrverband Kläranlage, Schmallenberg (Germany) which is mainly fed with municipal wastewater
- Laboratory culture: no
- Preparation of inoculum for exposure: The samples were not washed with mineral medium, since it was not necessary, but kept aerobic until use
- Pretreatment: no
- Concentration of sludge: 29,5 mg dry mass/L - Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Initial conc.:
- 32 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to guideline
- Additional substrate: no
- Solubilising agent (type and concentration if used): no
- Test temperature: 22 +/- 1°C
- pH: 7.4 +/- 0.2
- pH adjusted: yes
- Aeration of dilution water: not reported
- Suspended solids concentration: 29.5 mg/L
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: respirometer
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: The activated sludge was kept in aerobic conditions until use. The test suspension was aerated during the whole test
- Measuring equipment: SAPROMAT respirometer (Voith Inc.)
- Test performed in closed vessels: yes
- Details of trap for CO2: no details reported
SAMPLING: The measurement and recording of the oxygen demand was carried out continuously throughout the test.
CONTROL AND BLANK SYSTEM
- Inoculum blank: performed
- Abiotic sterile control: performed
- Toxicity control: performed
- Other: procedural/functional control with the reference substance sodium benzoate performed
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 100
- St. dev.:
- 1.4
- Sampling time:
- 28 d
- Remarks on result:
- other: test substance concentration: 32 mg/L
- Parameter:
- % degradation (O2 consumption)
- Value:
- 81
- St. dev.:
- 0.4
- Sampling time:
- 28 d
- Remarks on result:
- other: test substance concentration: 100 mg/L
BOD5 / COD results
- Results with reference substance:
- The reference substance sodium benzoate was biodegraded by 88% after 14 d and the requirement of the guideline (>60% biodegradation after 14 d of incubation) is fulfilled.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The ready biodegradation of the diethyl carbonate was investigated in a study conducted according to OECD Guideline 301 F. The test item proved to be readily biodegradable and fulfilling the 10-d-window criterion (100% and 81% biodegradation after 28 d of incubation at test substance concentrations of 32 and 100 mg/L, respectively).
- Executive summary:
The ready biodegradation of the diethyl carbonate was investigated in a study conducted according to OECD Guideline 301 F over a period of 28 days and using activated sludge as inoculum collected from a sewage treatment which is mainly fed with municipal wastewater. The biodegradation rate was determined by measurement of oxygen consumption. Inoculum blank, procedural/functional control with the reference substance sodium benzoate, and toxicity control using 100 mg/L test item and 100 mg/L reference compound were performed.
This study is regarded as reliable without restriction and satisfies the guideline requirements for ready biodegradation.
The test item proved to be readily biodegradable and fulfilling the 10-d-window criterion (100% and 81% biodegradation after 28 d of incubation at test substance concentrations of 32 and 100 mg/L, respectively). The functional control reached the pass level > 60% after 14 d. In the toxicity control containing both test and reference item 72% biodegradation based on oxygen consumption occurred within 14 d thus indicating that the test item was not inhibitory at the concentration tested.
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