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EC number: 203-311-1 | CAS number: 105-58-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity of the structurally related carbonate ester dimethylcarbonate to Selenastrum capricornutum was investigated in a study conducted according to EU Method C.3. The 72 h NOEC and EC50 (based on growth rate and biomass) were determined to be >100 mg/L and > 57.29 mg/L based on the nominal and geometric mean measured concentrations, respectively.
Key value for chemical safety assessment
Additional information
For the toxicity of diethyl carbonate (DEC) several study results are reported, both on the substance itself as well as on structurally related carbonate esters exhibiting the same mode of action. Taken together, the available data clearly document the low toxicity of DEC on different aquatic algae. For the effect of DEC on the growth of the green alga Scendesmus sp, an EC50 of 70.4 mg/l is predicted by the OECD-Toolbox 3.1.0. The calculation of the toxicity of diethyl carbonate to green algae yielded 96 h EC50 values ranging from 47.6 to 68.8 mg/L and chronic values ranging from 9.3 to 21.6 mg/L using ECOSAR v1.00. The structurally related carbonate ester dimethyl carbonate (DMC) was investigated on its toxic effect towards Selenastrum capricornutum (new name: Pseudokirchnerella subcapitata) in a study conducted according to EU Method C.3 (Algal Inhibition test; 1992). In this static limit test, the algae were exposed to a nominal concentration of 100 mg DMC/L for 72 h. The concentrations of dimethyl carbonate in the test media were assessed by chemical analyses (GC/FID). Dimethyl carbonate proved to be not toxic to exposed algae up to the highest test substance concentration applied and so the 72 h NOEC and EC50 (based on growth rate and biomass) were set to >100 mg/L and > 57.29 mg/L based on the nominal and geometric mean measured concentrations, respectively. These results were supported by values predicted by the OECD-Toolbox 3.1.0 for the algae Scendesmus sp, Scendesmus subspicatus as well as Selenastrum capricornutum (new name: Pseudokirchnerella subcapitata): EC50 and NOEC (endpoints biomass, growth rate) >= 62 mg/l
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