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EC number: 701-374-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test was run at concentrations well in excess of the water solublity limit.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 87/302/EEC, Algal inhibition test [Comparable to OECD 201]
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reaction products of triphenyl phosphite and isodecanol (1:2)
- EC Number:
- 701-374-4
- Cas Number:
- 25550-98-5
- Molecular formula:
- C26H47O3P
- IUPAC Name:
- Reaction products of triphenyl phosphite and isodecanol (1:2)
- Details on test material:
- - Name of test substance: Irgastab CH 300 (CAS# 25550-98-5)- Commercial, purity: Stated to be ‘within specifications’- Commercial batch no. 09520538 (Test identification code: TK 11211) - Supplier: Ciba-Geigy, Ltd, Basel, Switzerland
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- not specified
- Details on test solutions:
- The stock solution was made up of 100.2 mg of test substance mixed into 1000 mL of water. Calculated amounts of the stock solution to produce the desired test concentrations were added to the water and were homogeneously distributed.
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- TEST ORGANISM
- Common name: Green algae
- Strain:
- Source: Pflanzenphysiologisches Institut Univerity, Gottingen, Germany
- Age of inoculum (at test initiation):
- Method of cultivation:
ACCLIMATION
- Acclimation period:
- Culturing media and conditions (same as test or not):
- Any deformed or abnormal cells observed:
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
Test conditions
- Hardness:
- No data
- Test temperature:
- 23 +/- 1oC
- pH:
- The pH values of the water ranged from 7.8-7.9 at 0 hours and 8.5 to 9.0 at 72 hours
- Dissolved oxygen:
- No data
- Salinity:
- No data
- Nominal and measured concentrations:
- The measured test substance concentrations were determined by HPLC to be <0.01, 1, 3.8, 12.1, 33.7, and 107.8 mg/L at 0 hours and <0.01, 0.3, 2.0, 5.9, 21.4, and 75.6 mg/L at 72 hours for the blank and the target concentrations of 1.23, 3.7, 11, 33, and 100 mg/L, respectively.
Nominal target concentrations of 1.23, 3.7, 11, 33, and 100 mg - Details on test conditions:
- The algae were transferred into the flasks for a total duration of 72 hours. Samples of each test concentration were drawn immediately before exposure and at the end of the experiment and kept at 18-22 oC until analysed.
TEST SYSTEM
- Test vessel: 100-mL Erlenmeyer flasks
- Type: closed, stoppered with aluminum caps
- Material, size, headspace, fill volume: 50 mL of test solution per flask.
- Initial cells density: initial cell density of 10100 cells/mL were used in this experiment.
- No. of vessels per concentration (replicates): Nominal target concentrations of 1.23, 3.7, 11, 33, and 100 mg of test substance/L were used and each test concentration was tested in 3 replicates.
- No. of vessels per control (replicates): The blank control (water) was tested in 6 replicates.
OTHER TEST CONDITIONS
- Light intensity and quality: continuous illumination of white fluorescent light (approx. 8000 lux)
EFFECT PARAMETERS MEASURED: Cell densities were measured at 24, 48, and 72 hours on a “TOA” cell counter. The EC-50 values were calculated according to the maximum likelihood method, logit model. - Reference substance (positive control):
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 45 mg/L
- Basis for effect:
- growth rate
- Remarks on result:
- other: 25-67 mg/L
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.3 mg/L
- Basis for effect:
- growth rate
Any other information on results incl. tables
The mean cell densities (cells/mL x 10000) were as follows:
24 hr 48 hr 72 hr
Blank 6.0 27.1 147.3
0.3 mg/L 5.2 28.3 142.8
2.0 mg/L 5.2 26.3 19.5
5.9 mg/L 5.1 23.7 122.7
21.4 mg/L 4.6 23.5 102.8
75.6 mg/L 2.9 10.5 41.7
The mean inhibition levels for the blank control and the 0.3, 2.0, 5.9, 21.4, and 75.6 mg/L test substance groups were 0.0, 1.8, 15.0 16.0, 26.2, and 69.6%, respectively.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- no
- Conclusions:
- 72-hr EC50 = 45 mg/L. This study was run at concentrations well in excess of the water solubility limit of this phosphite and therefore the results are questionable. Regardless, this study supports the conclusion that this substance is not toxic to aquatic plant life at or below its water solubility limit.
- Executive summary:
72-hr EC50 = 45 mg/L. This study was run at concentrations well in excess of the water solubility limit of this phosphite and therefore the results are questionable. Regardless, this study supports the conclusion that this substance is not toxic to aquatic plant life at or below its water solubility limit.
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