Reaction products of triphenyl phosphite and isodecanol (1:2)

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

Other (1980). [Comparable to OECD Test Guideline 403].

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Reaction products of triphenyl phosphite and isodecanol (1:2)

EC Number:

701-374-4

Cas Number:

25550-98-5

Molecular formula:

C26H47O3P

IUPAC Name:

Reaction products of triphenyl phosphite and isodecanol (1:2)

Details on test material:

- Name of test material (as cited in study report): Diisodecyl phenyl phosphite
- Commercial, purity: Not stated (Phosphorus content = 7.09%)
- Lot/batch No.: PDDP-002-03240A
- Supplier: Borg Warner Company, Parkersburg, WV)

Test animals

Species:

rat

Strain:

other: Sherman/Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Housing: The animals were housed and maintained in compliance with the Animal Welfare Act (Pub. L-94-279) 9 CFR, Part 3.

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: plexiglass exposure chamber
- Exposure chamber volume: 260-L
- Source and rate of air: rate of flow through the chamber was 20 L/min
- System of generating particulates/aerosols: The material was administered as an aerosol, which was generated by a six-jet Collision nebulizer (BGI Incorporated, Waltham, MA). The air was passed through a desicant prior to being passed through the test material.
- Temperature in air chamber: 70oF.
- The average concentration of the aerosol over the one-hour exposure period was calculated to be 11.7 mg/L, by differential weighing of the flask from which the aerosol was generated.
- The particle size (mass median diameter) of the aerosol of the test material was determined to assure that the animals received a respirable dose and was determined using an Andersen Sampler cascade impactor. The sampler was run for 5 minutes midway through the exposure. During sampling, air from the breathing zone of the animals was drawn through the cascade impactor at the rate of 1 ft3/min. The amount of aerosol impacting on each plate of the Andersen Sampler was determined by differential weighing. From these values the mass median diameter of the aerosol was calculated to be 0.70 microns and the concentration was calculated to be 0.24 mg/L.

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

1 h

Concentrations:

The sample was dosed as supplied (described as a colorless to straw-colored liquid).

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 21 days
- Frequency of observations and weighing:

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 11.7 mg/L air

Mortality:

No animals died during the experiment

Clinical signs:

other: No adverse effects were observed during the one-hour exposure period. No untoward signs and symptoms were observed during the 21-day post-exposure observation period.

Gross pathology:

Gross pathological examination revealed no remarkable findings.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Remarks:

Migrated information

Conclusions:

No adverse effects were observed during the one-hour exposure period at exposures up to 11.7 mg/L (11,700 mg/m3). No untoward signs and symptoms were observed during the 21-day post-exposure observation period.

Executive summary:

No acute toxicity observed after a 1 -hr exposure of the whole animal to an aerosol of the test material. This study was run at concentrations well in excess of the saturated vapor level of the substance.