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EC number: 442-680-5 | CAS number: 443688-20-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 12th to 23rd, 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- 92/69/EEC
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Red LF 6339
- IUPAC Name:
- Red LF 6339
Constituent 1
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- Analysis was performed before incubation, after 2.4 hours and after 120 hours
- Buffers:
- - pH: 4, 7, 9
- Composition of buffer: Buffer pH4, Bipthalate; Buffer pH 7, Phosphate; Buffer ph 9, Borate - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: Erlenmeyer flasks 50 ml
- Sterilisation method: all glassware rinsed with sterile buffer
Preliminary test
performed at 50 °C ± 0.5 °C at each of pH 4.0, 7.0 and pH 9.0. Aliquots of each test solution were analysed in time intervals using the analytical method.
A main study was not performed since the test item was found a stable according to the criteria given in the guideline.
Preparation of test solutions
pH 4.0: a 9.40 mg sample was dissolved in 100 ml buffer solution (pH 4.0) with aid of sonication to prepare a test solution of 94.0 μg/ml test material. Two aliquots of this test solution of approximately 50 ml each were transferred into 50 ml Erlenmeyer flasks in order to perform a duplicate test.
pH 7.0: a 14.52 mg sample of test material was dissolved in a 100 ml buffer solution (pH 7.0) with aid of sonication to prepate a test solution of 145.2 μg/ml test substance. Two aliquots of this test solutio of app 50 ml each were transferred into 50 ml Erlenmeyer flasks in order to perform a duplicate test.
pH 9.0: a 10.15 mg sample of test material was dissolved in a 100 ml buffer solution (pH 9.0) with aid of sonication to prepate a test solution of 101.5 μg/ml test substance. Two aliquots of this test solutio of app 50 ml each were transferred into 50 ml Erlenmeyer flasks in order to perform a duplicate test.
Duration of testopen allclose all
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 94 other: μg/ml
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 145.2 other: μg/ml
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 101.5 other: μg/ml
- Number of replicates:
- 2
Results and discussion
- Preliminary study:
- Hydrolysis reaction after 5 days incubation
pH 4 = 1 %, 2 %
pH 7 = -1 %, 0 %
pH 9 = 0 %, 0 % - Transformation products:
- not measured
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Other kinetic parameters:
- The results of pH 4.0, pH 7.0 and pH 9.0 showed no significant degradation of the test item at 50 °C.
The degradation of the test item was less than 10 % after 5 days.
Applicant's summary and conclusion
- Conclusions:
- hydrolytically stable
- Executive summary:
The hydrolysis determination of the test material at different pH values was based on the OECD Guideline No. 111, "Hydrolysis as a Function of pH"; adopted May 12, 1981 and on the EEC Directive 92/69, Section C.7, "Abiotic Degradation: Hydrolysis as a Function of pH", L383 A, December 1992.
The results of pH 4.0, pH 7.0 and pH 9.0 showed no significant degradation of the test material at 50 °C. The degradation of the substance was less than 10 % after 5 days.
According to the EEC Directive 92/69, Section C.7 it can be concluded, that the estimated half-life time is higher than one year under representative environmental conditions (25 °C).
Therefore, the substance was considered to be hydrolytically stable, and no further testing was necessary.
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