Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-711-2 | CAS number: 689-67-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
- Reference Type:
- secondary source
- Title:
- Acute toxicity studies on 6,10-dimethyl-5,9-undecadien-2-one
- Author:
- BASF AG
- Year:
- 2 008
- Bibliographic source:
- RIFM database
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- internal BASF method; basically, method described in OECD 401 was used
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 6,10-dimethylundeca-5,9-dien-2-one
- EC Number:
- 211-711-2
- EC Name:
- 6,10-dimethylundeca-5,9-dien-2-one
- Cas Number:
- 689-67-8
- Molecular formula:
- C13H22O
- IUPAC Name:
- 6,10-dimethylundeca-5,9-dien-2-one
- Details on test material:
- - Name of test material (as cited in study report): Geranylaceton R
- Substance No.: 77/274
- Analytical purity: min. 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: own colony, BASF AG
- Age at study initiation: 4 - 5 weeks
- Weight at study initiation: mean: 177 g (male), 160 g (female)
- Diet (e.g. ad libitum): Rockland rat diet, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 31.6 - 50%
- Amount of vehicle (if gavage): 10 and 13.62 ml - Doses:
- 3160, 4640, 6810
- No. of animals per sex per dose:
- 5 - 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: prior to begin of study
- Necropsy of survivors performed: yes - Statistics:
- Most probable LD50 value and its fiducial range are estimated by the method of Thompson using the Tables of Weil.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 6 800 mg/kg bw
- Mortality:
- no deaths occurred
- Clinical signs:
- dyspnea, apathy, staggering, signs of excissose
- Body weight:
- - females showed reduced gain of weight in the beginning
- Gross pathology:
- no findings
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
