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EC number: 700-910-4 | CAS number: 1354201-99-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 June - 9 August 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Also in accordance with GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- O,O-bis(2-methylpropyl) sulfanidylphosphonothioate; trimethylazanium
- EC Number:
- 700-910-4
- Cas Number:
- 1354201-99-2
- Molecular formula:
- C11H28NO2PS2
- IUPAC Name:
- O,O-bis(2-methylpropyl) sulfanidylphosphonothioate; trimethylazanium
- Test material form:
- solid
- Remarks:
- pale yellow glassy solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): S-10713
- Physical state: solid
- Colour: brown
- Storage condition of test material: at room temperature in the dark
- Lot/batch No.: S20227-179
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories UK Ltd, Leicestershire, UK
- Age at study initiation: 12-20 weeks
- Weight at study initiation: 2.35-2.78 kg
- Housing: individually in suspended cages
- Diet: free access to 2930 Teklad Global Certified Rabbit diet (Harlan Laboratories UK Ltd., Oxon, UK)
- Water: free access to mains drinking water
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-23
- Humidity (%): 30-70
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: 28 June - 9 August 2011
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Remarks:
- moistened with 0.5 ml distilled water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 g - Duration of treatment / exposure:
- 3 minutes, 1 hour and 4 hours (first rabbit)
4 hours (two subsequent rabbits) - Observation period:
- 14 days
- Number of animals:
- 3
- Details on study design:
- COVERAGE
At three sites on the back of one rabbit the test substance was introduced under a 2.5 x 2.5 cm cotton gauze patch secured with surgical adhesive tape and the trunk was wrapped in an elasticated corset. Two additional rabbits were only exposed at one site for 4 hours.
REMOVAL
Any residual test substance was removed with cotton wool soaked in distilled water.
SCORING SYSTEM
According to OECD 404.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.66
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: slight desquamation at day 7
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: desquamation at day 7
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: dermal haemorrhage in centre of test site (approx. 8x12 mm) till 72 hours; slight desquamation or hardened dark brown/black colour scab at day 7
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritant / corrosive response data:
- Very slight erythema was noted immediatly after patch removal after 3-minute exposure (1/24/48/72h score 0 for erythema and edema).
There was no evidence of skin irritation after 1 hour exposure (all scores 0).
After 4-h exposure very slight or well-defined erythema and very slight to moderate oedema were noted at two treated skin sites immediately and one hour after patch removal. Well-defined erythema and very slight or slight oedema were noted at all treated skin sites at the 24 and 48-h observations. Well-defined erythema and very slight or slight oedema were noted at two treated skin sites with very slight erythema and very slight oedema noted at the remaining treated skin site at the 72-h observation.
An area of dermal haemorrhage, approximately 8x12 mm in size, was noted in the centre of one treated skin site one hour after patch removal and at the 24, 48 and 72-h observations with a hardened dark brown/black coloured scab, which prevented accurate evaluation of erythema and oedema, noted at the 7-day observation. This treated skin site appeared normal at the 14-day observation. Slight desquamation was noted at two treated skin sites at the 7-day observation. - Other effects:
- All animals showed expected gain in body weight during the study.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is slighlty irritating, but not sufficient for classification according to EC Regulation 1272/2008.
- Executive summary:
In a skin irritation study performed according to OECD 404 and EC 440/2008 B4 and following GLP principles, rabbits were exposed to the test substance for 3 min, 1h and 4h under semi-occlusive condtions.
No signs of skin irritation were noted after 3 min and 1h of exposure (Erythema and Edema scores at time points 24, 48 and 72h were all 0).
After 4-h exposure very slight or well-defined erythema and very slight to moderate oedema were noted at two treated skin sites immediately and one hour after patch removal. Well-defined erythema and very slight or slight oedema were noted at all treated skin sites at the 24 and 48-h observations. Well-defined erythema and very slight or slight oedema were noted at two treated skin sites with very slight erythema and very slight oedema noted at the remaining treated skin site at the 72-h observation.
An area of dermal haemorrhage, approximately 8x12 mm in size, was noted in the centre of one treated skin site one hour after patch removal and at the 24, 48 and 72-h observations with a hardened dark brown/black coloured scab, which prevented accurate evaluation of erythema and oedema, noted at the 7-day observation. This treated skin site appeared normal at the 14-day observation. Slight desquamation was noted at two treated skin sites at the 7-day observation.
Based on the results, the test material is not considered as irritating to skin and no classification is required.
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