Registration Dossier
Registration Dossier
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EC number: 940-766-1 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- (1E,5E,9E)-cyclododeca-1,5,9-triene; (1Z,5Z)-cycloocta-1,5-diene; 4-ethenylcyclohex-1-ene
- EC Number:
- 940-766-1
- Molecular formula:
- unspecified
- IUPAC Name:
- (1E,5E,9E)-cyclododeca-1,5,9-triene; (1Z,5Z)-cycloocta-1,5-diene; 4-ethenylcyclohex-1-ene
- Details on test material:
- - Name of test material (as cited in study report): Cycloocta-1,5-dien (constituent of registered reaction mass)
- Analytical purity: pure (not indicated)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Bruenger
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The test substance was administered as a 2 - 20% aqueous emulsion with Traganth.
- Doses:
- 0.2, 1.6, 3.2, 6.4 ml/kg
- No. of animals per sex per dose:
- 5 in the 2 lower doses, 10 in the two higher doses
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 2 992 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 3.4 mL/kg bw
- Mortality:
- 0.2 and 1.6 ml/kg: no deaths
3.2 ml/kg: 4/10 after 7 days
6.4 ml/kg: 10/10 after 7 days - Clinical signs:
- other:
- Gross pathology:
- sacrificed animals: nothing abnormal detected
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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