Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
other: All information in this endpoint has been provided by the ECHA using the 12 year rule, this data is not owned by the registrant . The reliability is estimated to be at level 2 at a minimum.
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
All information in this endpoint has been provided by the ECHA using the 12 year rule, data are not owned by the registrant. The reliability is estimated to be at level 2 at a minimum. Therefore the reliability statement below can be used: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of relevant results.

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
424-240-4
EC Name:
-
Cas Number:
96478-09-0
Molecular formula:
C18 H17 N3 O3
IUPAC Name:
2-[3-(2H-1,2,3-benzotriazol-2-yl)-4-hydroxyphenyl]ethyl 2-methylprop-2-enoate

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
not specified
Vehicle:
other: moistened with distilled water
Controls:
no
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
4 hours
Observation period:
7 days
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Remarks:
animal 1
Basis:
mean
Time point:
other: mean of 24,48 and 72 hours
Score:
0
Max. score:
4
Reversibility:
other: no effects observed
Irritation parameter:
erythema score
Remarks:
animal 2
Basis:
mean
Time point:
other: mean of 24, 48 and 72 hours
Score:
0
Max. score:
4
Reversibility:
other: no effects observed
Irritation parameter:
overall irritation score
Remarks:
animal 3
Basis:
mean
Time point:
other: mean of 24, 48 and 72 hours
Score:
0
Max. score:
4
Reversibility:
other: no effects observed
Irritation parameter:
edema score
Remarks:
animal 1
Basis:
mean
Time point:
other: mean of 24, 48 and 72 hours
Score:
0
Max. score:
4
Reversibility:
other: no effects observed
Irritation parameter:
edema score
Remarks:
animal 3
Basis:
mean
Time point:
other: mean of 24, 48 and 72 hours
Score:
0
Max. score:
4
Reversibility:
other: no effects observed
Irritant / corrosive response data:
No effects observed in any of the test animals
Other effects:
None

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The test material has not produced any effects of irritation to the animals within this study, therefore the test material can be classed as not classified.
Executive summary:

The study has been conducted according to Method B4 of Commission Directive 92/69 EEC. The test material has not produced any effects of irritation to the animals within this study, therefore the test material can be classed as not classified.