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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 700-891-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Oral acute toxicity tests were performed on four members of this category (covering C12-C22 alkyl polyglucosides) according to OECD 401 guideline.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The category of C12-22 alkyl polyglucoside is built with substances of Unknown or Variable composition, Complex reaction product or Biological material (UVCB substances). The substances in this particular category are consisting of fatty alcohols (even numbered) with mono and di-glucosides, called alkylpolyglucosides. Each category member is manufactured from fatty alcohol and glucose. All the members of this category are either mixture of fatty alcohols reacted with glucose or blends of alkyl glucosides of various chain lengths and degrees of polymerization.
The alcohols of substances included in this category are saturated linear compounds with a chain length from 12 to 22 carbons (even numbered), and the alkylpolyglucosides are formed of a hydrophobic carbon chain, with the same length, linked to one or two glucoses. The polymerization rate is close to 1 (1.2 to 1.5).
The starting material 12-hydroxystearic alcohol is composed of saturated linear alcohols with a chain length of 18 carbons and thus falls into the category.
Oral acute toxicity tests were performed on four members of this category (covering C12-C22 alkyl polyglucosides) according to OECD 401 guideline. All these members display a LD50 > 2000 mg/kg bw per day.
Dermal acute toxicity tests were performed on three members of the category covering C14 -C22 alkylpolyglucosides according to OECD 402. All these members display a LD50 > 2000mg/kg bw per day.
Considering the close similarity with regards to APG C12 hydroxy, one assumed that this compound was part of the category, which represented the whole range of alkyl polyglucosides compiled in this group.
Therefore, this category of C12-22 alkyl polyglucoside including “acetalization product between glucose and 12-hydroxystearyl alcohol” is concluded as getting a LD50 (oral) > 2000 mg/kg bw per day and a LD50 (dermal) > 2000 mg/kg bw per day.
Justification for classification or non-classification
As a result of the read-across approach based on grouping of the seven substances in a category, the LD50 (oral) and the LD50 (dermal) of the substance are concluded to be > 2000 mg/kg bw per day which results in no classification for both routes of exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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