Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-860-4 | CAS number: 100-52-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Two relevant studies on the impairment of fertility caused by benzaldehyde are mentioned in the German MAK report on benzaldehyde (1998).
10 female rats were given oral doses of 2 mg benzaldehyde per animal (about 5 mg!kg body weight and day) every second day for a period of 223 days, and were mated with untreated males on days 75 and 108 after the beginning of treatrnent. The control group consisted of 10 untreated females. The number of offspring. the weight of the pups after 1 and 3 weeks and survival of the pups was in the range of the control values. The number of pregnant females in the lest group was decreased relative to that in the control group (Sporn et al. 1967). The study design (small number of treated animals, only one dose group) does not meet present-day standards and cannot, therefore, be regarded as evidence of impairrnent of female fertility. In a medium-terrn study with male F344 rats (for more details see Section 5.2.2) decreased testis weights were observed, but the effective dose of 800 mg/kg body weight (dissolved in corn oil, administered by gavage) was highly toxic and led to the death of 6 of 10 animals, so that this finding cannot be regarded as evidence of an impairment in fertility. In the 400 mg/kg group, in which there were no deaths or signs of intoxication, this effect did not occur (Kiuwe et al. 1983, NTP 1990).
Effects on developmental toxicity
Additional information
There are no developmental toxicity studies available.
Justification for classification or non-classification
The above presented data on impairement of fertility, are not sufficient and conclusive for classification.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
