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Diss Factsheets
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EC number: 221-221-0 | CAS number: 3033-77-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: EU Risk Assessment report
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Although the EU risk assessment report is secondary literature, all data and risk assessment for the human, health and the environment have been evaluated and reviewed by Finland prior to publication. The risk assessment report has been submitted to final approval and published in the Official Journal of the European Union C157/10 dated on 21.06.2008. Thus, it is considered the information reported are reliable with the restrictions that reliability of the data presented has not been assessed again.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- European Union Risk Assessment 2,3-epoxypropyltrimethylammonium chloride CAS RN 3033-77-0 Einecs No: 221-221-0
- Author:
- EC
- Year:
- 2 008
- Bibliographic source:
- Risk Assessment. Final approved version. Rapporteur: Finland (FIN). European communities. Printed in Italy. 147pp
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Patch tests: the test substance was applied on patient's back and the application time was usually 24h. The results were read 24, 48 and 72h after the
removal.
Prick tests were performed with x standard allergens.
Test material
- Reference substance name:
- 2,3-epoxypropyltrimethylammonium chloride
- EC Number:
- 221-221-0
- EC Name:
- 2,3-epoxypropyltrimethylammonium chloride
- Cas Number:
- 3033-77-0
- Molecular formula:
- C6H14NO.Cl
- IUPAC Name:
- N,N,N-trimethyl(oxiran-2-yl)methanaminium chloride
Constituent 1
Method
- Type of population:
- occupational
- Route of administration:
- dermal
Results and discussion
Any other information on results incl. tables
Tables of results of the patch tests performed in patients allergic to EPTAC
Cases report (1)
Case |
1 |
2 |
3 |
4 |
EPTAC 1% |
++ |
+++ |
+++ |
No tested |
EPTAC 0.5% |
No tested |
No tested |
No tested |
++ |
EPTAC 0.2% |
++ |
+++ |
+++ |
++ |
EPTAC 0.1% |
No tested |
No tested |
No tested |
++ |
EPTAC 0.05% |
No tested |
+ |
No tested |
No tested |
Cases report (2)
Patient number 3 reacted "++" to 0.2% ECT and "+" to 0.1%. The other two had weaker "?+" and "+" reactions. Prick tests were negative, except in one case of pollen.
Cases report (3)
Test substance |
1 |
2 |
3 |
EPTAC 1% in petrolatum |
+++ |
++ |
++ |
EPTAC 0.5% in petrolatum |
+++ |
++ |
++ |
EPTAC 0.1% in petrolatum |
+ |
? + |
|
EPTAC 0.05% in petrolatum |
- |
- |
- |
Cases report (4)
Both patients test positive with 1% dilution of EPTAC. One of the patients had a positive, although slight, response already at 0.1% of the test substance.
Applicant's summary and conclusion
- Conclusions:
- Based on the positive results in the patch tests in humans, it can be concluded that EPTAC is a skin sensitizer.
- Executive summary:
In several cases of workers who developped skin disease caused by exposure to epoxy compounds, patch tests have been perfomed. Several dilutions of EPTAC have been applied in the back of patients with an application time of 24 hrs in general. The results were read 24, 48 and 72h after removal and dermatologist scored the skin reactions.
Positive test results showed that EPTAC is considered as a skin sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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