Registration Dossier
Registration Dossier
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EC number: 205-736-8 | CAS number: 149-30-4
Endpoint summary
Administrative data
Description of key information
Mercaptobezothiazole LOAEL = 750 mg/kg-day (based on decreased body weight gain in females) NOAEL = 375 mg/kg-day in 13 weeks study.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 375 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
At the dose of 3000 mg/kg-day, all of the rats died. Due to the high mortality, the initial study was terminated and a second one was conducted using the same testing protocol with the omission of the highest dose level (3000 mg/kg-day). In the second study, no treatment-related deaths occurred. Body weight gains were lower than those in the vehicle control groups in males at 1500 mg/kg-day and in females at 750 or 1,500 mg/kg-day. Hepatomegaly occurred at 750 and 1500 mg/kg-day in males and at all doses in females; however, no microscopic pathologic changes were noted in any tissue. LOAEL = 750 mg/kg-day (based on decreased body weight gain in females) NOAEL = 375 mg/kg-day
Justification for classification or non-classification
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