Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-019-7 | CAS number: 7783-66-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The genotoxic potential of fluoride was investigated in three in vitro studies and in one in vivo study. Hydrogen fluoride was tested in an Ames test both with and without S9 activation (Herbold 1987). The salmonella mutants tested were the strains TA 1535, TA 100, TA 1537 and TA 98. The substance was tested up to a concentration of 1800 µg per plate (at higher concentrations cytotoxicity was observed). There was no evidence of mutagenic activity at any concentration tested with and without metabolic activation. The results of the chromosome aberration test were inconclusive (NTP 1990). The two laboratories used to test the effects of sodium fluoride on CHO cells showed conflicting results; one reported a negative result and one reported a positive result for both induction of sister chromatid exchanges and chromosomal aberrations. The mutagenic activity of sodium fluoride was also tested in a mammalian cell mutagenicity study under neutral and acidic conditions in the V79/HGPRT system (Slamenova 1996). Sodium fluoride treatment did not result in any mutagenic activity. An in vivo micronucleus test and chromosome aberration test also indicated no mutagenicity of fluoride (Zeiger 1994). Mice were exposed to sodium fluoride via the drinking water for 1 or 6 weeks. No evidence of micronuclei formation was seen in peripheral blood erythrocytes after 1 or 6 weeks and no evidence of chromosomal aberration was seen in bone marrow cells after exposure for 6 weeks.
The genotoxic potential of potassium iodate was investigated in vitro, using the alkaline comet assay and the cytokinesis-block micronucleus assay (Poul 2004). The comet assay did not detect the presence of DNA damage after a treatment with potassium iodate at concentrations up to 10 mM. This absence of primary DNA damage (DNA strand breaks and abasic sites) after potassium iodate exposure was confirmed by the absence of clastogenic effects in the cytokinesis-block micronucleus assay. In conclusion, the results clearly indicated that potassium iodate had no mutagenic effects in CHO cells at concentrations up to 10 mM.
Furthermore, the results of a 2-year oral (drinking water) study with potassium iodide (KI) in rats do not raise concern with regard to carcinogenicity of iodine (Takegawa, 2000). In this study squamous cell carcinomas (SCC) occurred in the submandibular salivary gland of a few rats of both sexes at the highest dose level tested (1000 ppm KI in the drinking water, corresponding to 53 and 67 mg/kg bw/day in male and female rats, respectively) but no treatment-related tumors were observed in the thyroid or other organs and tissues. The accompanying histopathological changes in the salivary gland (focal acinar atrophy, ductular proliferation, squamous metaplasia in the epithelium of proliferating ductules) suggested that the SCC resulted from an epigenetic mechanism, only active at high doses. The dose at which SCC were seen in the rat study is about 4000-5000 times higher than the tolerable daily intake (TDI) for iodine of 0.01 mg/kg bw/day established by the World Health Organisation (WHO, 2009). Taken together, these data indicate that the iodine moiety of iodine pentafluoride does not present a risk with regard to carcinogenicity.
Short description of key information:
No studies with iodine pentafluoride are available. However, reliable studies with the read-across substances sodium fluoride, hydrogen fluoride and potassium iodate do not indicate mutagenicity of fluoride or iodate.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Due to the fact that the substance violently reacts with moisture and produces hydrofluoric and iodic acids, classification for toxicity is based on fluoride and iodate according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 and according to EU Directive 67/548/EEC. Since IO3- and F- are not mutagenic, no classification is needed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.