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Registration Dossier
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Diss Factsheets
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EC number: 203-565-3 | CAS number: 108-26-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study report, no relevant route of exposure
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- 2,4-dihydro-5-methyl-3H-pyrazol-3-one
- EC Number:
- 203-565-3
- EC Name:
- 2,4-dihydro-5-methyl-3H-pyrazol-3-one
- Cas Number:
- 108-26-9
- Molecular formula:
- C4H6N2O
- IUPAC Name:
- 2,4-dihydro-5-methyl-3H-pyrazol-3-one
- Details on test material:
- Name of the test substance used in the study report: Methylpyrazolon feucht ber. 100%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult animals with a comparable weight were used (age at study start: about 12 weeks).
Acclimatization period: at least one week
Five animals per cage (type: stainless steel wire mesh cages, DK-III).
The animals were identified via cage cards.
Room temperature: 20 - 26°C
Relative humidity: 45 - 75%
Day/night rhythm: 12 h light and 12 h darkness
The animals were offered a standardized animal laboratory diet as well as tap water ad libitum. Food depreviation 16 hours before substance administration (water was available ad libitum).
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- 0.5% aqueous CMC; the aqueous suspension corresponds to the physiological medium.
Concentration used: 21.5% (G/V)
Application volume: 10 ml/kg - Doses:
- 2150 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Observation period: 18 days
Recording of signs and symptoms: < 15 min, 15 min, 30 min, 1 h, 2 h, 4 h and 5 h after administration, then once on working days. Check for moribund or dead animals twice each working days and once on public holidays.
16 hours before sacrifice food depreviation; then necropsy with macroscopic-pathological examination. Necropsy of animals that died as soon as possible.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 150 mg/kg bw
- Mortality:
- None
- Clinical signs:
- Dyspnea, apathy, staggering, trembling, urine light-orange coloured, ruffled fur, poor general state
- Body weight:
- Mean body weight male animals: 180 g at study start, 275 g after 13 days
Mean body weight female animals: 170 g at study start, 215 g after 13 days - Gross pathology:
- Sacrificed animals: nothing abnormal detected.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.