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EC number: 204-847-9 | CAS number: 127-52-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In contrast to the animal study for skin sensitisation, tested on Chloramine B trihydrate, human (case) studies were available on Chloramine T. A read-across justification was worked out and separately attached in Section 13. Based on the data from the repeated dose toxicity studies, as well as the comparable molecular structure and similar physicochemical properties, it was concluded that both data from Chloramine B trihydrate as those of Chloramine T and metabolites such as BSA and p- and o-TSA can be used for read-across.
In a key study (Plodikova, 2006) Chloramine B trihydrate, was tested for the assessment of skin allergic effects using albino guinea pigs.
The test was performed according to EU Method B.6, Skin sensitisation, which is analogous to OECD Test Guideline No. 406, Skin sensitisation. The Magnusson and Kligman maximization procedure was followed. The experiment proceeded in three phases: intradermal induction - topical induction – topical challenge. Potential skin reactions were evaluated at the end of experiment.
The test substance caused a positive reaction in 9 of 20 guinea pigs, e.g. in 45% of animals which were exposed to the test substance.
Migrated from Short description of key information:
A key study for skin sensitisation was performed according to EU Method B.6/ OECD TG. 406, i.e. Magnusson and Kligman maximization procedure . In this study, Chloramine B trihydrate caused a positive reaction in 9/20 guinea pigs, e.g. in 45% of animals, which was considered to be positive for skin sensitisation.
Justification for selection of skin sensitisation endpoint:
key study
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Cfr. Section 7.10 Sensitisation data (humans)
Migrated from Short description of key information:
No studies were available for Chloramine B trihydrate, however human case studies and reviews were available for Chloramine T. From these studies, it is clear that Chloramine T is a skin and respiratory sensitizer, therefore Chloramine B trihydrate may also be considered to be a human and respiratory sensitizer.
Justification for selection of respiratory sensitisation endpoint:
Based on human respiratory sensitisation data (case studies)
Justification for classification or non-classification
Chloramine B trihydrate needs to be classified for skin sensitisation according to the Directive 67/548/EEC, Annex VI with symbol Xi with the following risk phrase: R43 - May cause sensitization by skin contact. According to CLP regulation (No. 1272/2008 of 16 December 2008), Chloramine B trihydrate is classified as Category 1, with signal word 'warning' and hazard statement: H317 - May cause an allergic skin reaction.
Chloramine B trihydrate needs to be classified for respiratory sensitisation according to the Directive 67/548/EEC, Annex VI with symbol Xn with the following risk phrase: R42 - May cause sensitization by inhalation. According to CLP regulation (No. 1272/2008 of 16 December 2008), Chloramine B trihydrate is classified as Category 1, with signal word 'danger' and hazard statement: H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled.
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