Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 450-650-8 | CAS number: 51762-67-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study experimental phase 2013-10-28 to 2014-01-06. Study report complete 2014-05-23.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Meets the criteria for classification as reliable without restriction according to Klimisch et al (1997).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- no
- Principles of method if other than guideline:
- The Test Item was examined by Optical (Light) Microscopy and Laser Diffraction after the test sampe had been sieved through a 300um sieve.
Optical (Light) Microscopy was used to characterise the Test Item to allow a better understanding of its physical characteristics prior to laser diffraction analysis. This is a visual assessment to provide additional supporting information, e.g. the presence of agglomeration etc, to allow interpretation of the laser diffraction data and understand the limitations of the laser diffraction data.
Laser Diffraction was used to determine the particle size distribution of the Test Item and assess the MMAD (mass median aerodynamic diameter). - GLP compliance:
- yes
- Type of distribution:
- mass based distribution
Test material
- Reference substance name:
- -
- EC Number:
- 450-650-8
- EC Name:
- -
- Cas Number:
- 51762-67-5
- Molecular formula:
- C8H3N3O2
- IUPAC Name:
- 3-nitrobenzene-1,2-dicarbonitrile
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Results and discussion
- Mass median aerodynamic diameter:
- 243.142 µm
Particle sizeopen allclose all
- Percentile:
- D50
- Mean:
- 289.737 µm
- Remarks on result:
- other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
- Percentile:
- D10
- Mean:
- < 97.846 µm
- St. dev.:
- 0.667
- Percentile:
- D50
- Mean:
- < 289.737
- St. dev.:
- 1.005
- Percentile:
- D90
- Mean:
- < 617.105
- St. dev.:
- 2.066
Any other information on results incl. tables
Optical (Light) Microscopy
By direct observation the Test Item was observed to be a pale yellow powder.
With the 5x objective the particles appeared to be mostly irregularly shaped (no lines of symmetry) with a wide variety of sizes visible. With the 10x objective the particles appeared to be mostly irregularly shaped (no lines of symmetry) with a wide variety of sizes visible.
Coefficient of variation for d50 and d10 are less than 3%; d90 is less than 5%. Thus repeatability of the characteristic particles in the size distribution are within acceptable limits as per the ISO 13320-1 test standard.
Applicant's summary and conclusion
- Conclusions:
- By direct observation the Test Item was observed to be a pale yellow powder. With the 5x objective (light microscopy) the particles appeared to be mostly irregularly shaped (no lines of symmetry) with a wide variety of sizes visible. With the 10x objective the particles appeared to be mostly irregularly shaped (no lines of symmetry) with a wide variety of sizes visible.
The MMAD of the test material is 243.142um.
10% of the material has a diameter of <97.846um
50% of the material has a diameter of <289.737um
90% of the material has a diameter of <617.105um
Inhalable particles, which can be inhaled by nose and mouth, have a particle size of <100um. Therefore at least 10% of the test material has a particle size which can be inhaled by nose and mouth. - Executive summary:
Introduction
This study was undertaken to determine the particle size distribution of the test material. The Test material was examined by Optical (Light) Microscopy and Laser Diffraction after the test sampe had been sieved through a 300um sieve. Optical (Light) Microscopy was used to characterise the Test Material to allow a better understanding of its physical characteristics prior to laser diffraction analysis. This is a visual assessment to provide additional supporting information, e.g. the presence of agglomeration etc, to allow interpretation of the laser diffraction data and understand the limitations of the laser diffraction data. Laser Diffraction was used to determine the particle size distribution of the Test Material and assess the MMAD (mass median aerodynamic diameter).
Results & Conclusions
By direct observation the Test Item was observed to be a pale yellow powder. With the 5x objective (light microscopy) the particles appeared to be mostly irregularly shaped (no lines of symmetry) with a wide variety of sizes visible. With the 10x objective the particles appeared to be mostly irregularly shaped (no lines of symmetry) with a wide variety of sizes visible.
The MMAD of the test material is 243.142um. 10% of the material has a diameter of <97.846um. 50% of the material has a diameter of 289.737um. 90% of the material has a diameter of 617.105um.
Inhalable particles, which can be inhaled by nose and mouth, have a particle size of <100um. Therefore at least 10% of the test material has a particle size which can be inhaled by nose and mouth.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.