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EC number: 236-691-2 | CAS number: 13465-08-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- sub-chronic toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2007
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract available only, full publication in Chinese
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: Publication abstract
- Title:
- Acute toxicity and target organs assessment of subchronic exposure to hydroxylammonium nitrate in Wistar rats
- Author:
- An H., Liu S-X., G L-H., Ran H., Huan Y., Cao J.
- Year:
- 2 007
- Bibliographic source:
- Journal of Toxicology
Materials and methods
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Hydroxylammonium nitrate
- EC Number:
- 236-691-2
- EC Name:
- Hydroxylammonium nitrate
- Cas Number:
- 13465-08-2
- Molecular formula:
- H3NO.HNO3
- IUPAC Name:
- hydroxylammonium nitrate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 0.9% saline
- Details on exposure:
- Rats were administered hydroxylammonium nitrate
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 13 weeks
- Frequency of treatment:
- Not stated
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.00 (control), 7, 14, 28 mg/kg bw/day
- No. of animals per sex per dose:
- Not stated
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Rats were administered hydroxylammonium nitrate at doses of 0.00 (control), 7, 14 and 28 mg/kg for 13 weeks. After the last dose, 75% of the animals were sacrificed by cervical dislocation, the remaining animals were allowed a recovery period before sacrifice.
Examinations
- Observations and examinations performed and frequency:
- Not stated
- Sacrifice and pathology:
- Animals were sacrificed by cervical dislocation at either at the end of the treatment period (13 weeks) or after the treatment period and a recovery period (time not stated). The main target organs of subchronic exposure to HAN were evaluated.
- Other examinations:
- Not stated.
- Statistics:
- Not stated.
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Description (incidence and severity):
- Spleen weight was significantly higher in animals administered hydroxylammonium nitrate for all doses.
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Significant lesions occurred mainly in the lung, liver and spleen in animals administered hydroxylammonium nitrate.
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- Large deposits of hemosidering in the liver, spleen and kidneys in animals administered hydroxylammonium nitrate.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Rats administered hydroxylammonium nitrate via intraperitoneal injection at concentrations of 7, 14 and 28 mg/kg for 13 weeks displayed lesions in the lung, liver and spleen and had large hemosiderin deposits in the liver, spleen and kidney. There were no significant differences in bodyweight between control and experimental animals, although all concentrations of hydroxylammonium nitrate caused an increase in spleen weight in the experimental animals compared to control animals. There is no evaluation of the animals who were given a recovery period. A LOAEL of 7 mg/kg can be derived from this study based on changes in spleen weight.
- Executive summary:
Rats administered hydroxylammonium nitrate via intraperitoneal injection at concentrations of 7, 14 and 28 mg/kg for 13 weeks displayed lesions in the lung, liver and spleen and had large hemosiderin deposits in the liver, spleen and kidney. There were no significant differences in bodyweight between control and experimental animals, although all concentrations of hydroxylammonium nitrate caused an increase in spleen weight in the experimental animals compared to control animals. A LOAEL of 7 mg/kg can be derived from this study based on changes in spleen weight. The reliability of this study is not assignable.
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