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EC number: 204-552-5 | CAS number: 122-52-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (publicly available peer reviewed source). Original document not available.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.
- Author:
- OECD
- Year:
- 2 003
- Bibliographic source:
- UNEP Publications
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
- Version / remarks:
- (adopted 1981)
- Deviations:
- no
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Triethyl phosphite
- EC Number:
- 204-552-5
- EC Name:
- Triethyl phosphite
- Cas Number:
- 122-52-1
- Molecular formula:
- C6H15O3P
- IUPAC Name:
- triethyl phosphite
- Details on test material:
- Purity: 98.8%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Remarks:
- (400, Lutrol)
- Details on oral exposure:
- VEHICLE
- Amount of vehicle: 5 mL/kg bw - Duration of treatment / exposure:
- 32 days
- Frequency of treatment:
- Once daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
30, 150, or 750 mg/kg bw
Basis:
actual ingested
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent vehicle
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
DETAILED CLINICAL OBSERVATIONS: Yes
BODY WEIGHT: Yes
FOOD CONSUMPTION AND WATER CONSUMPTION: Yes
HAEMATOLOGY: Yes
Red blood cell count (RBC), hemoglobine (Hb), hematocrit (Hct), white blood cell count (WBC), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), Platelets, differential WBC, coagulation
CLINICAL CHEMISTRY: Yes
Alkaline phosphatase, aspartate amino transferase (ASAT), alanine amino transferase (ALAT), glucose, bilirubin, cholesterol, triglycerides, creatinine, total protein, urea, albumin, phosphate, calcium, chloride
URINALYSIS: Yes
Spec. gravity, volume, bilirubin, blood, Hb, ketones, pH, protein, sediment
NEUROBEHAVIOURAL EXAMINATION: No - Sacrifice and pathology:
- Necropsy: gross necropsy with collection of >50 tissues
Organ weights: brain, heart, testes, liver, lung, kidney, spleen, adrenal gland
Histopathology: heart, liver, spleen, kidney, adrenals of control and high dose animals; lungs of all animals; all macroscopically altered tissues. - Statistics:
- Mann-Whitney U-test at significance levels of p = 0.05 and 0.01.
Results and discussion
Results of examinations
- Details on results:
- CLINICAL SIGNS AND MORTALITY
750 mg/kg bw: impaired general condition, emaciation, umkempt fur, increased mortality (1 male and 1 female; another female was killed in moribund state)
150/30 mg/kg bw: No effects on mortality were seen.
BODY WEIGHT, FOOD CONSUMPTION, WATER CONSUMPTION:
750 mg/kg bw: reduction of all 3 parameters (body weight gain: - 37% (males), - 13% (females); food consumption: - 29% (males), - 15% (females); water consumption: - 28% (males), - 12% (females).
150/30 mg/kg bw: No effect on body weight gain, food and water consumption was noted.
HAEMATOLOGY
750mg/kg, males only: statistically significant increases in RBC, Hb, Hct, and granulocyte counts; decreases in MCH, MCV, and lymphocytes.
No relevant changes were found in males at 150 mg/kg bw and in females at any dose group with the exception of one single female of the 150 mg/kg bw group showing anisocytosis and changes in red and white blood which were interpreted as a chance event by the study authors.
CLINICAL CHEMISTRY
750 mg/kg bw: increases in alkaline phosphatase activity (males only), and decreases of plasma albumin (both sexes) and triglyceride concentrations (males only).
150 mg/kg bw: no relevant findings
URINALYSIS
750 mg/kg bw: reduced urine volume in males;
150 mg/kg bw: no relevant findings
ORGAN WEIGHTS
750 mg/kg bw: increases in relative lung weights (males: +65%, females +69% as compared to the controls) and in absolute lung weights in females (+46%). Increases in relative adrenal weights (+33% in males, +30% in females), in relative kidney weights (+32% in males, +17% in females), and in relative liver weights (females only, +17%).
150 mg/kg bw: no effect on organ weights
GROSS PATHOLOGY:
750 mg/kg bw: lungs: brown stains in all animals that survived to the end of the study. The male that had died during the study showed dark lungs and yellow spots in the epididymides.
HISTOPATHOLOGY: NON-NEOPLASTIC
750 mg/kg bw:
lungs: focal inflammation (all males, 4 females), and fibrosis (4 males, 4 females); hyperplasia of bronchial epithelium in all animals. Foreign material was found in the lungs of 3/10 animals. In the animal that died during the study, sperm granulomas were noted in the epididymidis.
150 mg/kg bw: no pathological changes.
30 mg/kg bw: foreign material was found in the lung of a single animal, together with a minimal inflammatory response in the lung. As this effect was not noted in any other animal of this dose group the study authors assumed that it might have been caused by aspiration following an error in the gavage procedure.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 150 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: Pathological and histopathological effects on the lung.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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