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EC number: 271-239-8 | CAS number: 68526-91-0 A complex combination of hydrocarbons produced by the distillation of products from the hydrogenation of isotridecanal from the hydroformylation of dodecene. It consists predominantly of C13-14 primary aliphatic alcohols, C22-28 dimer alcohols, C26 acetals and esters, and C>10 acid sodium salts and boils in the range of approximately 250°C to 450°C (482°F to 842°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Dodecene, hydroformylation products, high-boiling
- EC Number:
- 271-239-8
- EC Name:
- Dodecene, hydroformylation products, high-boiling
- Cas Number:
- 68526-91-0
- Molecular formula:
- Unspecified
- IUPAC Name:
- Reaction products of dodecene, hydroformylation products, high boiling
- Details on test material:
- - Batch No.: Tk253_20090901
- BASF Test Item No.: 08/0016-3
- Purity: 99.7 area-%; dose calculation not adjusted to purity
- Stability in solvent: The stability of the test substance in the vehicle was verified indirectly by a concentration control.
- Storage: At room temperature
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- other: CBA/CaOlaHsd
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories B.V., AD Horst / The Netherlands
- Age at study initiation: 8 - 12 weeks
- Weight at study initiation: 17.7 - 21.8 g
- Housing: Single caging
- Diet (e.g. ad libitum): Pelleted standard diet, ad libitum
- Water (e.g. ad libitum):Tap water, ad libitum
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2
- Humidity (%): 21-65
- Photoperiod (hrs dark / hrs light): 12 hours/12 hours
Study design: in vivo (LLNA)
- Vehicle:
- methyl ethyl ketone
- Remarks:
- for the test item; vehicle for the positive control: Acetone:olive oil (4+1)
- Concentration:
- 25, 50 or 100% test
item concentration - No. of animals per dose:
- 5 animals
- Details on study design:
- RANGE FINDING TESTS:
- Compound solubility: A solubility experiment was performed according to the recommendations given by OECD 429. The highest test item concentration, which can be technically used was 100 % of the undiluted test item.
- Irritation: To determine the highest test item concentration that does not induce local signs of skin irritation or systemic toxicity, a pre-test was performed in two animals. Two mice were treated with test item concentrations of 50 and 100% each on three consecutive days. In the pre-test clinical signs were recorded within 1 hour and 24 ± 4 hours after each application as well as on day 6. At the tested concentrations the animals did not show signs of excessive local irritation as confirmed by the ear thickness measurements. An increase in ear weight of about 13.4 % was observed in the animal treated with the undiluted test item (100 %) in comparison to the animal treated with 50% test item concentration. However, this was not considered as a severe sign of local irritation. Also, the animals did not show any signs of systemic toxicity.
TREATMENT PREPARATION: The test item was placed into a volumetric flask on a tared balance and methyl ethyl ketone was quantitatively added. Test item solution at different concentrations was prepared by serial dilution. The preparations were made freshly before each dosing occasion. - Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
- Statistics:
- For all statistical calculations SigmaStat for Windows (Version 2.0) was used. A One- Way-Analysis-of-Variance was used as statistical method. In case of significant results of the One-Way-ANOVA, multiple comparisons were performed with the Dunnett test and the Student Newman Keuls test.
Results and discussion
- Positive control results:
- Mean DPM per group:
Vehicle: 988.7
25 % Positive Control: 7155.5
SI:
25 % Positive Control alpha-Hexylcinnamaldehyde (mean): 8.24 (Statistically significant increase in comparison to the control (vehicle) group (p=0.008))
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: see Remark
- Remarks:
- 25 % Oxooel 13 (mean): 2.98 (Statistically significant increase in comparison to the control (vehicle) group (p<0.001)) 50 % Oxooel 13 (mean): 4.86 (Statistically significant increase in comparison to the control (vehicle) group (p<0.001)) 100 % Oxooel 13 (mean): 9.92 (Statistically significant increase in comparison to the control (vehicle) group (p<0.001))
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: 0 (mean): 1124.3 25 % (mean): 3348.1 50 % (mean): 5468.1 100 % (mean): 11155.5
Any other information on results incl. tables
Calculation of the EC 3 value:
Test item concentration % | S.I. | |
Test Group 2 | 25 (a) | 2.98 (b) |
Test Group 3 | 50 (c) | 4.86 (d) |
EC3 = (a-c)[(3-d)/(b-d)] + c = 25.3 % (w/v) |
EC3 = Estimated concentration for a S.I. of 3.
a,b,c,d = Co-ordinates of the two pairs of data lying immediately above and below the S.I. value of 3 on the LLNA dose response plot
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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