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Diss Factsheets
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EC number: 225-924-3 | CAS number: 5153-24-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A GLP-compliant OECD guideline 406 study (Magnusson-Kligman maximisation) test with guinea pigs was available (BASF AG, 1987). A group of 20 female Dunkin-Hartley guinea pigs was induced intradermally with0.1 ml Freund's adjuvant without the test substance emulsified with water (ratio 1:1), 0.1 mL of 25% dilution in water of the test substance and 0.1 mL Freund's adjuvant/water (1:1) with test substance. One week later the animals were induced epicutaneously with a single 48 hours application of the unchanged test substance under occlusive conditions. Two control groups were induced intradermally with the same injections, but without the test substance. No epicutaneous induction was performed, since the test substance was applied unchanged and no solvent was used. Approximately 14 days after epicutaneous induction, the animals of the test group and of the first control group were challenged at the untreated site epicutaneously for 24 hours with the unchanged substance under occlusive conditions. The animals of the second group remained untreated. The readings of the skin reactions were performed ca. 24, 48 and 72 hours after the beginning of application. One week later a rechallenge was performed, in which animals of all groups were treated with the test substance for 24 hours under occlusive conditions and the readings were performed after 24, 48 and 72 hours.
After intradermal induction distinct erythema and edema were observed at the injection sites of the control animals and the test animals which were applied with Freund's adjuvant/water (1:1). The test substance formulation in water or Freund's adjuvant/water (1:1) caused necrotic skin changes and distinct edema in the test animals. No skin changes were observed in the control animals which were applied with solvent. After percutaneous induction, necrotic skin changes caused by the intradermal induction were observed in addition to distinct edema.
The percutaneous challenges with the unchanged test substance did not cause any skin changes either in the test group or in the control groups. The scores were 0 at all time points in all animals. Based on the results of the study, the substance is concluded to be not sensitising to the skin.
Migrated from Short description of key information:
Based on the results of a GLP-compliant OECD guideline 406 (Magnusson-Kligman assay) study, zirconium di(acetate) oxide is not considered a skin sensitiser.
Justification for classification or non-classification
Based on the negative results in the GLP-compliant OECD Guideline 406 study (Magnusson-Kligman assay), classification of zirconium di(acetate) oxide as a skin sensitiser according to EU Directive 67/548 and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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